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But we can't assume that the voluntary response to a mail-in study is the same as population prevalences. See this study for example. Men might be less likely to be diagnosed with ME/CFS, less likely to network with others with the disease and so hear about the study, and less likely to...

Copied post But we can't assume that the voluntary response to a mail-in study is the same as population prevalences. See this study for example. Men might be less likely to be diagnosed with ME/CFS, less likely to network with others with the disease and so hear about the study, and less...

Five to one is a very high ratio. Yes, it says 'up to five-to-one', which covers a lot of ground, but still. I don't think it gives an accurate representation of what we know. You yourself (Simon) said this on the epidemiology thread, suggesting a ratio of 3 to 1 or 4 to 1. The first meta...

Posts copied from Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al Five to one is a very high ratio. Yes, it says 'up to five-to-one', which covers a lot of ground, but still. I don't think it gives an accurate...

Yes, and even then, it only suggests that rather than shows it, with there not being any clear biomarker. There is not yet any smoking gun here.

I agree Kitty. That first paragraph of the paper seemed to me to be giving the question of physical inactivity undue weight. It also seemed to be taking an overly negative view of exercise. People with cardiovascular disease are in fact often encouraged to be active and even to do some...

Not sure I can add much to @rvallee's spot-on analysis. But 'promising'? Pretty much everyone with a disease like ME/CFS works out a version of 'activity pacing' in the first 6 months. People give up things, often very important things, in order to reduce the activity they do. It's not news...

Is that a typo in the abstract? Should it be Of 3,237 traits considered, ME status restricted activity had a significant effect on only one, via the "Duration of walk" ?

Thanks for posting @Amw66 “Position-dependent function of human sequence-specific transcription factors” by Sascha H. Duttke, Carlos Guzman, Max Chang, Nathaniel P. Delos Santos, Bayley R. McDonald, Jialei Xie, Aaron F. Carlin, Sven Heinz and Christopher Benner, 17 July 2024, Nature. DOI...

There was a lot here that I found worth thinking about. I'm not the target audience - I think therapists would find the paper worth reading, and I'd like them to read it. I wonder if the academic language would be off-putting, as it was to me. Perhaps the author could consider writing a...

Second part of the paper - what 'psy practitioners' can do to be better and actually help. My comments here aren't necessarily a summary of what is said but my response and ideas of actions that might flow from the points made. be aware of oppressive power systems; assist people with personal...

I struggle with the language that I guess is part of this academic field, but there are interesting ideas e.g. The 'you are making a big deal over nothing and seeking attention, dear, just get on with things as a man would'. I do wonder if this plays into the lower rates of diagnosis of these...

From that thread:

There is some discussion of it in this post and some that follow in that thread: FREE Long Covid and ME/CFS Holistic Healing VIRTUAL SUMMIT July 10-16, 2023

From the discussion: Ref #53 is Plasma Markers of Neurologic Injury and Inflammation in People With ... Neurologic Post acute Sequelae of SARS-CoV-2 Infection, 2022, Peluso et al That study only found elevated GFAP early in the disease of those with Long Covid, and not later. I get the...

I note the affiliation of the senior author: Matthew Campbell View ORCID ID profile Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland...

I've just looked at reference 65 - thread here Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment, 2024, Greene et al Although the cohorts were small (e.g. 11), the results from the MRI with contrast did look pretty...

Coming back to this, given that Nath recently said that he was confident that there is no blood brain barrier dysfunction in Long Covid. The findings on blood-brain barrier dysfunction based on the MRI scanning with contrast still look pretty good.

The abstract of the preprint is in 2023 is in the first post and the published abstract is at this post. It looks as though the paper received quite a bit more polishing. Also, there's substantially more on gene expression.

Montpellier, France It wasn't that difficult to believe the disease could be chronic. But at least this team understands that there is no treatment. (Perhaps 'basic' is a translation error? perhaps meaning 'disease-modifying'?) I'm aware that Jonathan doesn't think much of the idea of NETs...