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This was interesting, for beyond the Gulf War: They talk about how smoking can reduce PON1 efficiency and how that could explain some modification of risk associated with being a smoker. They also talk about how the pyridostigmine bromide may have increase vulnerability for both RR veterans...

I'm sorry, I'm still confused how they determined PON1 status and what they mean by it. I think they just mean the functional phenotype. Discussion But, the good news - it seems their findings do fit with what is known about the biology of the PON1 forms. That's something to hang onto. The...

3.4 Association of exposures with GWI case status Table 4 shows that a range of exposures were associated with GWI case status. E.g. 86% of GWI cases heard chemical alarms sound versus 64% of controls. Adjusted odds ratio of 1.7 83% of GWI cases took the pyridostigmine bromide versus 60% of...

Results Demographics Females accounted for 18% of GWI cases and 15% of veteran controls. I don't know if the selection of the cohorts was on a population basis or if there was some selection If PON1 status is determined by PON1 function, then of course PON1 status is going to vary by PON1...

PON1 status assays I think they must have identified the actual PON1 genotype, but I'm not 100% sure. Ed. I don't think they determined PON1 genotype - reference 35 only talks about determining PON1 function using substrates. They definitely determined the function i.e. the enzyme activity in...

Methods 398 veterans from three pre-existing cohorts. 295 GWI cases and 103 controls That sentence is slightly worrying. Hopefully the Gulf War veteran controls were actually healthy and not in some no mans land of being ill but not quite ticking the right boxes to be considered to have GWI...

Introduction

We have split off posts primarily about sex ratios to a new discussion thread dedicated to that topic: ME/CFS Epidemiology - sex ratios, female predominance

There is the interchangeability of the ME and CFS diagnoses, and the varying popularities of the two diagnoses over time. It seems likely to me that the higher prevalence of an ME diagnosis aged 80+ could be explained by those people receiving that diagnosis back in the 1980s, when they were in...

The English translation is often pretty loose. There's obviously a lot of jibes and jokes where you need a bit of German background, but so many good points are made. Satire is such an effective tool for changing/creating public opinion.

This is a fantastic initiative, I hope it will help to ensure that there is safe professional psychological support for people with ME/CFS and similar conditions who want it. It would be wonderful to have a good resource to direct people to. Great to see the process includes lots of...

Not sure if that is a question, but no, no posts were moved but I did another post on that topic here: ME Epidemiology - prevalence, peak ages of onset and gender ratio I totally agree with @Ravn about the Introduction and the lack of a need to get into the details of ME/CFS epidemiology. I...

Abstract Background Few longitudinal studies available characterize long COVID outcomes out to 24 months, especially in people with nonsevere acute coronavirus disease 2019 (COVID-19). This study sought to prospectively characterize incidence and duration of long COVID symptoms and their...

On the idea that most people improve and even recover in the first two years: 43 Servier, C., Porcher, R., Pane, I., Ravaud, P. & Tran, V.T. Trajectories of the evolution of post- COVID-19 condition, up to two years after symptoms onset. Int J Infect Dis 133, 67-74 (2023). Forum thread French...

Abstract Objectives: We aimed to identify trajectories of the evolution of post-COVID-19 condition, up to 2 years after symptom onset. Methods: The ComPaRe long COVID e-cohort is a prospective cohort of patients with symptoms lasting at least 2 months after SARS-CoV2 infection. We used...

Results Just because gender ratios are top of my mind at the moment: I do think the tendency for women to be in public facing roles with a high exposure to infections, such as nursing and teaching, may influence ME/CFS sex ratios. Contrast general ME/CFS with Q fever fatigue syndrome. Farmers...

Introduction Method

From a discussion on another thread about a claimed sex ratio in ME/CFS of 5 to 1: I know the issue of sex ratios issue isn't very important in a paper about biomarkers, but there are good reasons to try to get it as right as possible in published papers. I'm a bit surprised about the belief...

So as to not take the thread off topic, I'll address the arguments about the sex ratio used in this paper on the epidemiology discussion thread. ME/CFS Epidemiology - sex ratios, female predominance