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Yes. So, until we have a biomarker, I don't think reported prevalence of ME/CFS in age classes over 65 tell us much and are best ignored when trying to work out overall prevalence. New diagnoses in older people are even more subjective and prone to clinician preference than usual.

Huh? I haven't looked beyond the abstract, but perhaps it would have been good to have defined 'symbolic violence' in there somewhere?

I thought it was worth highlighting this recruitment process for a research nurse in The Netherlands ME/CFS Cohort and Biobank consortium (NMCB)

:rofl: I've changed the title to add a couple more sciencey words, hopefully adding a bit more credibility to the term. You should be able to change the title Ravn, (top right, thread tools, edit thread), but very possibly something is not working right. Message me with a new title if you...

Thanks @Ravn, I don't think I've heard of stress granules before. I wondered where you were going with them to start with; they sounded a bit like ear seeds, or small stress balls. There has been some talk of the role of heat shock proteins in ME/CFS, and here is a suggestion that heat shock...

Yes, I think you are right. The Context in the NICE ME/CFS Guidelines isn't too bad to cite in an introduction, for research relevant to England and Wales anyway. At least it's an authoritative source.

From the Daily Mail article: Dr Monro certainly sounds problematic, but the commentary about her could just as easily be said about many doctors promoting psychosomatic beliefs, some of them eminent. In fact, it could just as easily be said about too many doctors with all sorts of beliefs...

On payment, yes, it depends on the study and on the PwME. There's the option of PwME opting not to be paid, or having their payment be donated to a charity. And of course, it's not feasible for every study to pay for PPI. There are lots of different ways to do things. A Masters student could...

I'm late to the party, but a pile on of congratulations seems in order. Well done Trish, and my thanks to Sonya for the decisive action.

I think finding out about opportunities is a major barrier to participation. Reduced capacity to do things is obviously a barrier to participation. That makes it especially important that there is information to allow an accurate weighing of the benefits and costs. Lack of that information is...

Interesting, thanks Mij. Notable that having Long Covid was said by the judge to have given rise to a functional neurological disorder. That's slightly weird - I would have thought the hypothesis would be for FND to be the result of Covid-19. Long Covid (the persistent symptoms) essentially...

Thank you forestglip. From a quick google, those top metabolites (that were lower in the ME/CFS samples) all seem to be associated with defence against pathogens. Certainly worth having more of a look at them.

@forestglip, thank you. How does the correlation work? All the correlation signs are negative. Is there a way to tell if a metabolite is up or down in the ME/CFS people?

The Results section is terrible. There is no raw data given, the outcomes are all hidden behind models supposedly calculating outcomes with regression equations based on baseline data. Totally opaque. Sex is a variable in the equations, and I don't think they even tell us which is higher, male...

They struggled to get the planned cohort - which suggests word is getting around. As well as the three patients excluded or who withdrew, there is missing data in lots of the measures. There is missing data for six patients' baseline 6 minute walking data. Always a bit worrying when the data...

Worth noting the people involved. They all should be embarrassed. Journal of Psychosomatic Research Stefan Salzmann ab; Mirko Herrman c; Markus Henning c; Lisa Schwertner c; Frank Euteneuer d; Lara Goldau a; Celine Bahr a; Christoph Berwanger c; Winfried Rief a a Clinical Psychology and...

Incredible The people who expected to get worse with the BPS treatment got worse. The people who expected to get better with BPS treatment got worse. Conclusion: 'Managing patient expectations is crucial for optimal rehab outcomes." (e.g. lower the bar for "success") Look at the title...

@Thanks @chillier. Yes, what you have said makes sense to me. I'm not yet completely clear whether the situation is 1. most likely, the BCHE values for both males and females PwME sit within the 95% confidence interval for healthy people, albeit the male PwME data is mostly above the healthy...

BCHE The z score for BCHE in ME/CFS men is over 5 (for women it's heading towards 2). Given the z score of 5, I'm not understanding your hypothetical scatter plot. Shouldn't the ME/CFS data points be a lot higher? I could easily be misunderstanding something there. I'm quite keen on the...

From the 2023 poster, 102 patients from family medicine consultations (from one practice? in Charleroi, Belgium). 66.3% female As I understand it, the SPECT scan with that tracer can show areas of relative hypoperfusion. I'm not sure if SPECT scans can show decreased brain perfusion compared...