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"‘Symptom Invalidation’ in Clinically Uncertain Diagnoses Can Leave Lasting Mental Health Harms" (Medscape, June 2025): https://www.medscape.com/viewarticle/symptom-invalidation-clinically-uncertain-diagnoses-can-2025a1000ewd

It's a conference abstract; if you're logged in all you get extra is the ability to download the abstract as a PDF. From the RCPCH conference in March.

Two other Maes papers assessing neopterin: (a) this one [link] - "[p]atients with ME/CFS showed significantly higher values for IL-1, TNFα, neopterin and elastase than those with CF"; (b) also, this one [link] (J. Affect. Disord, 2013), which seems quite confused in places. Two other papers...

Haven't reviewed them in detail but, at a quick glance, there seem to be a few other errors in the references - some examples under the tag. What potentially confirmatory experimental approaches would you envisage being of most use - flow cytometry, scRNA-seq, ELISPOT, CITE-seq? Tsuda et al...

It's up! Abstract: Evidence bearing on possible mechanisms for the clinical syndrome of ME/CFS is reviewed. The evidence is used to argue for a hypothesis that centres on a form of persistent, inappropriate, ‘neuroimmune hypervigilance’ mediated primarily by T lymphocyte-macrophage interaction...

Abstract: Evidence bearing on possible mechanisms for the clinical syndrome of ME/CFS is reviewed. The evidence is used to argue for a hypothesis that centres on a form of persistent, inappropriate, ‘neuroimmune hypervigilance’ mediated primarily by T lymphocyte-macrophage interaction but...

Now published - see post #17 Abstract: Background/Objectives: Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may report abnormalities in voice and speech; however, no formal research has been conducted in this area. Methods: An online mixed-methods survey was...

I just realised why this paper sounded so familiar, as well as the reference to an anonymous donor - there was a thread on the preprint...

A previous study by this group was Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions (Helliwell et al., 2020). From a quick glance: very similar methodology (although DMAP + single-CpG MethylKit vs DMAP2 in the more...

Don't have the energy to look it up at the moment but I'm sure I've seen previous ME/CFS related papers by this group also contain a declaration that they were funded by an anonymous donor.

Now published in Nature Genetics: https://www.nature.com/articles/s41588-025-02100-w

I've (very briefly) skimmed through all of the available chapters. As would be expected from a Springer Protocol it is intended for lab researchers. For those unfamiliar, an example: Generally discussion on S4ME doesn't reach this level of methodological granularity. The two chapters that would...

Now published - link here Preprint Abstract Post-viral conditions, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID (LC), share >95% of their symptoms, but the connection between disturbances in their underlying molecular biology is unclear. This study investigates...

I remember TPPP appeared as possibly implicated in Hajdarevic et al: Link | S4ME thread

For what it's worth I'm rather sceptical that the concept of IACCs is at all a useful one - I previously explained why I think that in this post: https://s4me.info/threads/thereforme-campaign-building-an-nhs-that’s-there-for-long-covid-and-me.39467/page-14#post-581342

Had a quick glance at the paper itself. Very brief summary of the GWAS results of significance: * rs145088940 (HAS2) - CDCsevere - only in cross-ancestry meta-analysis of the non-deployed * rs138168412 (AOPEP) - KSsymptoms in non-deployed veterans / eQTL effects * rs142258944 (BMPR1B) - CDC...

And a few more:

The quote is from this thread's paper, Sun et al. Haven't read the full paper yet but in addition to PSMD7 & 8 (non-ATPase regulatory subunits of the 26-S proteasome, not TFs), I think also NFKBIA is an inhibitor of the NF-κB TF complex, not a TF itself. Not familiar with SCENIC but not sure why...

Another excellent & well-argued rapid response (and, I think, the first cite for S4ME's PEM factsheet): "Ignorance about post-exertional malaise and continued conflation of ME/CFS with chronic fatigue harms patients and stymies research progress" (Dom Salisbury)...

Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex heterogeneous multiorgan disease that can have severe impact on individuals' quality of life. Diagnosis of ME/CFS is based on symptom presentation, and a significant goal for the field is to establish meaningful...