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Something else I find hard to understand is why these CKS summaries are going out under the NICE name & branding, yet are being produced by a private company with apparently no opportunities for patient or public involvement. It seems to make a mockery of the NICE guideline procedure if...

Well, this is why it's so bad - it's based in part on those BACME guides:

Abstract: Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-Acute Sequelae of COVID-19 (PASC) often have neurocognitive complaints that involve memory and concentration problems and difficulties paying attention. Other neurocognitive domains such as...

In addition a number of references are also duplicated - e.g. 8, 9, 10 are duplicated as 13, 14, 15.

Re follow-up of the Behan result, there was also: Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue Syndrome (Plioplys & Plioplys, 1995) Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome (Lane et al., 1998)

"Third delay to ME care plan prompts backlash from patients" (The Times): Link | Archive.ph link | 12ft link

From the referenced 2020 narrative review in Med. J. Aust. - seems deeply problematic in its coverage of CBT & GET: https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50553

"Trial By Error: Dutch Journalist Faces Off Against CBT/GET Ideologues": https://virology.ws/2025/06/25/trial-by-error-dutch-journalist-faces-off-against-cbt-get-ideologues/

Chlorine dioxide is typically used as a disinfectant or bleaching agent. It is toxic and corrosive and definitely not meant for human consumption. If any doctor is promoting this as a treatment for any disease they should be struck off.

Copied post Re Carson: what puzzles me is why he is seen as an expert on ME/CFS. The only relevant link seems to be that, according to Carson's declared interests on the SMC's website he "led writing of the Scottish Good Practice Statement in ME/CFS in 2008" - but how did he manage to get...

Copied post Re Carson: what puzzles me is why he is seen as an expert on ME/CFS. The only relevant link seems to be that, according to Carson's declared interests on the SMC's website he "led writing of the Scottish Good Practice Statement in ME/CFS in 2008" - but how did he manage to get...

I also don't see any significant overlaps with the results in Pu et al. - has Carson even skimmed through either paper, or is he just winging it?

The years don't match, but are you thinking of this 2011 JNNP commentary that reflects on his well-known 1989 paper? https://jnnp.bmj.com/content/83/1/4

The no-a-priori-hypothesis claim is silly - there's a clear research question & rationale for the methodology; it's not some fishing expedition. I've only skimmed the paper but think he's conflating the cross-sex replication set (116) with the total (511) & the 150-by-chance/116 observed is...

The main NDE/NIE models didn't include BMI (only age & sex) but following peer review comments (comment 3, p16 of the peer review) they re-estimated the blood-trait NDEs with BMI as an additional confounder. Fig. EV5 shows male vs. female-specific BMI adjusted z-scores. So the classical...

A notable addition to the published version - made at the request of one of the peer reviewers - was a replication attempt of 14 of the traits using the US-based "All of Us" programme (Fig 8, p13):

Now published: Link | PDF (EMBO Molecular Medicine, June 2025, open access) The peer review is also available: https://www.embopress.org/action/downloadSupplement?doi=10.1038/s44321-025-00258-8&file=44321_2025_258_MOESM1_ESM.pdf The Times has a piece on it: Link | Archive.ph link | 12ft...

Abstract: Background/Objectives: The aetiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic and severe debilitating disease with a complex phenotype, remains elusive. Associations with infectious diseases and autoimmune and neuropsychiatric disorders have been...

I downloaded this paper a few days ago but have only just got around to looking at it - it is unintentionally very revealing regarding the lack of evidence for BPS services. 1/ The authors relate that, in 2023, an MEA complaint to the Advertising Standards Authority regarding a programme known...

"SNOMED CT Coding: Optimising ME/CFS and Long COVID Care": https://meassociation.org.uk/2025/06/snomed-ct-coding-optimising-me-cfs-and-long-covid-care/