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The figures of 50-80% of people with CFS having Chiari suggest that most of these patients are even less likely to have had Chiari than ME/CFS. They just got better for some reason. It seems like the same story has had two waves of popularity. It is interesting to note that Peter Rowe thought...

I think Garner and Carson are on solid ground in their critique of 'micro-clots' which aren't even micro-clots, they are precipitates in test tubes. I think the researchers are still at the stage of trying to find out whether they have measured anything real to be honest. The story around micro...

Thread split from The itaconate shunt hypothesis A wild card theory I have toyed with for some years is that the pathogenic signalling in ME/CFS may be invisible because it is 'written on the walls' in tissue. In an underground train (metro) system, travellers need not carry any instructions...

The key thing, Chris @MelbME, is to remember not to try to teach this load of grannies to suck eggs. Or at least, by all means try - I do it all the time and I enjoy savouring the potential dents to my intellectual self-esteem that would inevitably result if I were not myself something of a...

Presumably "Retsina" is out of patent after 2500 years.

I believe it's quite common on this website when people read some threads. And violent with it.

So he believes in Psychosomatic Exertion Malaise??

I think someone is overstepping the evidence base and speculating.

Did you manage to access this @ME/CFS Skeptic ?

https://ovidsp-ovid-com.libproxy.ucl.ac.uk/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=ovft&AN=00006114-199301000-00024&PDF=y this may work @ME/CFS Skeptic but you need to paste it into the search line, otherwise you get something from El País!

I am absolutely sure that is the case. But slowing the blood won't help the brain metabolically. And if neurone are very active they may want the oxygen tension to be well up near optimal even in the venules. It may not at all like draining all the oxygen out. A bit like a Chinese paintbrush. It...

The laboratory cabinet used by Thomas Lewis when discovering the Triple Response due to histamine release.

That suggests that the tilt table test is of pretty little value as far as I can see.

It would normally but presumably if it hasn't already then there is some reason for not being able to. I don't think one can really make sense of this sort of line of thought without referring to particular cell types though. We have no idea whether any cells have mitochondrial problems let...

It doesn't really make much sense to me I am afraid. I think one would need to specify which cells were staying and which going. New cells come from old cells dividing. If the old cells were in trouble not sure why new cells would be better? Lots of cells you wouldn't want to get rid of and the...

For the reasons given in the post above. I am clinically familiar with that situation and it doesn't apply to people with ME/CFS - they do not have warm pink swollen legs in that way. But maybe there is a specific defect that does not occur in other circumstances.

It's a clever idea but I don't think it quite flies, does it? Slowing down blood could increase the oxygen extraction from a given volume of blood but what possible compensatory function could that have? To extract more oxygen over time you want faster flow and return to lungs as quick as...

Maybe it was a mind over body psychosomatic address.

That sounds complicated. Excessive venous pooling would presumably be due to vasodilation rather than constriction? Maybe venodilation in the presence of arterial constriction but if muscles are being used I would have thought blood would be pumped back to the heart OK. I am also not sure how...

If you look at my posts you will see that that is precisely my point,. POT doesn't seem to be mostly what is causing OI in ME/CFS patients. But that is how POT is defined. Sorry you are having a hard time, but I thin you are making things harder for yourself than needed.