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The article looks fairly poorly researched. A colloid cyst is not a tumour. If it was capable of causing severe depression it was probably capable of causing severe memory loss - as might the surgery have been. 300 ECT sessions is a huge number so it isn't representative of the usual situation...

I note that Darren Jones has been appointed as Chief Secretary to the Treasury. I met him at one point in the House of Commons in relation to his interest in ME/CFS and being on the science and technology committee. He has asked questions about ME/CFS research in the Commons

Probably more of sterile pneumonitis. I am not sue this has ever been adequately sorted out. Cell depleting monoclonals can produce serious acute events.

Which B cell experts? Maybe Andreas Radbruch I guess. Without an antibody to measure the only real issue is with re-treatment time. I suspect an initial trial will have to stick with a six month endpoint from a single infusion.

If virus persistence is contributing to Long Covid B cell depletion would seem risky. There were almost certainly excess deaths in patients on rituximab during the Covid epidemic and of course new variants are still making people ill and causing a few deaths.

I am rather unimpressed by this new fashion for talkings of 'NETs'. As far as I can see this is fibrinoid, which we all learnt about as students in 1970and which had been known about since the nineteenth century. Neutrophil debris combines with fibrin in (extravascular) tissue areas of...

yup!

Maybe people with non-coeliac gluten sensitivity live like that though? Some doing gluten free and some gluten restricted. As long as they were randomly assigned it wouldn't really affect controlling of the intervention.

I wonder what the patient information sheet said and whether it was ethical. If the 'expectation part' of the study was 'masked' from the patients it sounds as if the information sheet said that they would be told whether or not to expect gluten - but not told that the information would be...

It does seem a good change but there is another factor to consider. Seizures of various sorts often come in phases or batches with good periods and bad periods for novelly obvious reason. People will always tend to be recruited to trials during bad periods - they may need to have had a certain...

But do we have any evidence for the viral persistence having anything to do with the immune activation? It seems to me that there are a lot more unanswered questions out there than Peluso is claiming. In EBV there is viral perisistence. There is also prolonged immune activation involving CD8...

Yes, I am not wanting to argue that there is nothing worth doing. There are some things to follow up but the people concerned are likely to be doing that I=f they really believe their own results. My main point was simply that I don't think forum members should be criticised of responding their...

I can't see any spinal cord signal on the images but I have yet been able to through the detailed text.

I had forgotten we had seen at least the abstract a year ago. I looked at the images - because I am used to working with images - without looking at the descriptions first, to see if I could work out what was supposed to be abnormal. I couldn't see anything that wasn't consistent with v various...

@Caroline Struthers Caroline, You know that doesn't make sense. I was asked to give my expert witness testimony on problems with trials for ME/CFS to NICE precisely because it was known that I had such views and that they appeared to be relevant. Having a view is NOT a 'conflict of interest'...

My gripe is that they did not stop at publicising their results at every opportunity but produced highly speculative reviews about mechanisms that made little sense to me at least. To suggest that the micro clots actually caused symptoms or tissue damage really needed some sort of evidence of...

I am not sure that that is entirely fair. Pandemics are unusual situations where potential areas of treatment for review emerge as of nowhere very fast. And potentially very large numbers of people are put at risk by unproven therapies. I have been shocked as to who in the medical profession is...

I realise that. But I say what I do having spent a career in developing treatments from basic animal lab work to actually making up the infusions for my patients. I was sufficiently committed to getting a result that meant something for patients to spend $15,000 of my own cash on buying a drug...

Charles seems to have slightly missed the point of my article. I decided that further guidance was not required - the current guidance is enough to keep people alive. Although, I did suggest that setting up research to gain more evidence was a good idea.

So why haven't you done it already? I don't get this I am afraid.