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It looks as if these post-centrifugation aggregates occur in plasma from people whose coagulation systems are already partially activated in vivo. I wonder whether the aggregates are any better at telling that than standard coagulation screens. Since disseminated intravascular coagulation is...

Not so much problematic as barn door nonsense. Most walls have some cracked bricks. That doesn't mean that cracked bricks do not cause walls to collapse. Research that starts out with this level of stupidity might as well go in the bin from the outset.

Yer, well, some emeritus professors knows their stuff and others don't, seems to me. Fiona needs to learn a little about the real world of science and the phoneys who tag along.

Yer, well, some emeritus professors knows their stuff and others don't, seems to me. Fiona needs to learn a little about the real world of science and the phoneys who tag along.

Yet one commonly hears of ME patients being told they have gastroparesis. If it really exists in ME and causes severe weight loss why haven't physicians at least written case reports?

Interesting to see that this pain reprocessing therapy (PRT) seems to have been invented by an NIH project: https://www.nih.gov/news-events/nih-research-matters/retraining-brain-treat-chronic-pain It seems to have emerged from addiction, mental health and 'translational' departments but could...

Curable looks to be a rather nasty scam, certainly.

This is pure nonsense, propagated by people like Peter Rowe and Rodney Grahame, I'm afraid. Generalised joint hypermobility just means you have relatively stretchy ligaments around joints. 20% of the population are the 20% stretchiest. And 20% are the 20% least stretchy. Women are stretchier on...

This is my worry. I am not sure what easy digestibility would have to do with gastroparesis. High roughage foods are generally thought to be good, not bad. Once masticated and exposed to pepsin it is all pretty much a soup anyway I guess. My memory is that fat stimulates cholecystokinin, which...

Not that I am aware of? Diabetes produces generalised neuropathic changes so gastroparesis would not be surprising. We have no evidence of neuropathic changes in ME as far as I am aware.

Jessica Eccles has been suggesting Long Covid patients are bendy too: https://www.theguardian.com/society/2024/mar/19/people-with-hypermobility-may-be-more-prone-to-long-covid-study-suggests Usual Guardian gossip.

Ig protein levels vary a lot within normals and Vh gene usage has never turned out to tell us very much except perhaps for Vh4-34 which is anomalous. I suspect noise.

So what is 'best clinical evidence'? Are there good quality trials? The recent review article abstracts tend to suggest nobody has got very far either in terms of mechanism or treatment evidence. The only consistent documentation seems to relate to diabetes and whatever is wrong there may be...

But in ME/CFS patients, pieces of the virus or bacteria may linger in the body and continue to stimulate the immune system long after the infection should have resolved. Except that they didn't find that and it's a theory older than the hills. Apparently it is also good news that the problem is...

I had a look to see what had been published on gastroparesis and ME/CFS and on gastroparesis in general. My findings: Papers on gastroparesis and ME/CFS = 0. Papers on gastroparesis indicate a recognised problem in diabetes (unsurprising) after surgery and with certain infections although these...

I don't understand why there is no stratification to valacyclovir without celecoxib and vice versa. Any positive result can be ascribed to just taking celecoxib (controls not even being allowed to use another NSAID).

My understanding is that we have no firm evidence for regional paraesthesia being associated with ME. There are lots of potential causes. Sorting them out requires detailed neurological examination and imaging. Even with investigation a clear explanation is not always found. However, if symptoms...

Patients are desperate and patients need treatment. And we can't just wait to figure out the entire pathophysiology, like we need to start. I understand where Brian Vastag is coming from but it isn't so much that we haven't figured out the entire pathophysiology. It is that we still have no...

I don't think jam and sponge indiscretions over a few days will have any long term impact, however barmy they may be at the time. The NHS, as we all know, is falling apart and it does not surprise me that there is no sensible dietetic management but the important thing is to have a regular diet...

This group of diseases has by and large received little attention or funding in decades past — save for long Covid, which is relatively well-heeled at the moment through the RECOVER trial. Other conditions, including chronic Lyme, mast cell activation syndrome, Ehlers-Danlos syndrome, POTS, and...