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I think again that this is trying to be too clever and is unlikely ever to pan out to an established effect. They do not report purifying an Ig fraction that actually has the activity proposed - which would be the acid test. That last step is always the most difficult but if you don't do it the...

And that is what I would disagree with and warn may be a slippery road to go down. You are suggesting not so much correlation as identity. The same thing. Exertion (rather than exercise, as members have often reminded me) intolerance is not being able to tolerate exertion because of feeling...

Yes, happy to review a draft with a view to joining authorship.

But what is a 'cardinal marker'? Does cardinal mean the best available, or definitive, or always the case, or what? Does marker mean correlate or something in a causal relation? Generally marker means correlate, and that is the issue. As @EndME implies, the second day COET result might reflect...

Edit: This may just repeat Hutan's immediately prior post but I wrote it anyway! I am not sure what your rhetorical statement is intended to imply, @Mark Vink. I agree with Hutan that the 2 day CPET is not actually a measure of PEM and I am not sure it helps that much to say it documents 'PEM...

My guess is that you have to have symptoms first. If you feel bad on standing and that is associated with a 30bpm rise and no blood pressure fall then it gets called POT. If blood pressure falls it is called orthostatic hypotension. This may seem unjustified but there are other examples of...

I do not know the literature but I have seen it commented that a rise of 30bpm is not necessarily abnormal.

Blood flow to an organ depends only on average blood pressure and vessel calibre. There is no obvious reason why people with POTS should constrict brain vessels on standing so the only relevant change would be change in arterial pressure. Brain venous pressure would go down on standing which...

One thing do not understand is that people with 'POTS' are supposed to be at risk of low cerebral blood flow. Yet, if the BP is maintained (as it is by definition in POTS) and the heart rate goes up there is no reason why the brain should get less perfusion. It might get more.

I cannot make head nor tail of this. It is time these physiologists explained things more clearly and stopped using impenetrable jargon. I strongly suspect that you cannot deduce much from NIR spectroscopy because so many parameters may shift - much as others have suggested.

Humility is the key - and something drummed into me by my physician father but not something I always saw in colleagues to be sure. But I don't think this study is the answer. The reason you do not ask patients for accounts of the symptoms they think are important is largely that those symptoms...

A smorgasbord of excellent questions, @EndME. In fact that is pretty much exactly as we thought when I left off fifteen years ago and almost nothing has changed other than the appearance of CAR-T now. For RA we identified four crucial positive cycles, one of which was dependent on random...

My mother ate a lot of bananas and is now 102.

That study is underwhelming. They found some shifts in gene expression in circulating monocyte including it seems more CD16 (the main marker of 'non-classical' state). This sort of 'activation' of monocytes in the absence of something straightforward such as raised CRP or ESR is pretty hard to...

It is interesting to see this people getting themselves tied in knots about terminology. If psychological and biological cannot be distinguished then presumably there is no point in talking about a biopsychosocial model or publishing, as Wyller has, in 'Biopsychosocial Medicine'. He is being...

Maybe because nobody could work out what it means? I tried to understand it but it is couched in so much jargon that I could not work out even what they were measuring. They seem to have found increased 'distribution volume' in some places but less in another with p values that look marginal...

I can see it now - the Post Exercise-Pill Post-Exertion-Reminiscent Malaise In Non-exerTers trial.

I might do and I might not. Maybe I can feel it in my bones.

Do people think that this is a useful categorisation 'Energy-Limiting Conditions'? It is not something I am aware of medical professionals talking about. The net seems to be cast very wide - including about 7% of the population. Is it helpful in terms of educating authorities about the nature...

Lupus is under three or four medical specialities. It gets a relatively high level of research funding because medics find it interesting. Lupus research is done all over, without a lupus institute. My work on rheumatoid wasn't in a special rheumatoid institute. I had a small group and we made...