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We tried to do a trial of CBT (whatever that means in this instance) in renal fatigue but the patients thought we were stupid nosy-parkers. In the end some of them just about put up with us and our dumb theories - or pretended to. The results are consistent with the fact that nothing actually...

The prevalence figure if I remember rightly was intended to refer to multiple sclerosis, diabetes and RA, hence no citation, but I agree it is ambiguous. I agree that 0.2% prevalence is probably the most realistic figure but I disagree that broad criteria necessarily lead to bad research. It...

It is interesting to see people so ignorant. Science and evidence are two quite different concepts. My first degree was in Art History. Art History makes better use of evidence than medicine but that does not make it a science. It just makes it reliable - which is important for those investing...

I had burnout after four years of more or less single-handed development of a drug treatment that I knew might kill some of my favourite people. It probably did kill one. In the photos of me at the end I look about 101. I have always thought of my mental state as entirely normal.

RA makes your joints hurt and feel miserable. Surprisingly it is the same RA that does both!!

Sorry, but I disagree. The geneticists have a clear understanding of EDS which has been completely messed up by practitioners who should know better - very often with private practices but also pseudo-academic empires. The genetics of EDS have been subject to extensive research. The problem has...

I agree. But maybe 'meaning well' is only an excuse if it includes the humility needed to know when you don't know whether what you are doing will be helpful.

As far as I can see this is Dr J Tanner of Oving Clinic saying 'patients are very confused about CCI and to be honest I am pretty confused and cannot work out well enough what is what to give any useful information but my course of 3-4 injections could be good'. Dr Tanner is an osteopath

Behaviour can be reflex. I think this is the sort of talk that derives from the behaviourist approach - which basically denies the existence of the 'mental' other than in terms of input and output. Behaviour is any output you can measure.

The approach is just plain stupid. If you ask for people who are interested in doing a review of the effectiveness of X you will get applications from people who have a vested interest in showing the effectiveness of X. Anyone with a reasonable degree of scepticism and at least minimal knowledge...

Then why not call it ME/CFS (triggered by Lyme)?

The two are not necessarily alternatives, just different ways of categorising illness. Atherosclerosis and myocardial infarction can apply to the same person - they nearly always do.

All fair enough but I don't suppose anyone mentioned the likelihood that the pandemic itself was the results of such collaboration. Even if it wasn't, we know that practices were sufficiently lax for it to have been a real possibility. The negligence of the scientific community is unarguable...

Twaddle from Greenhalgh as usual. Any idiot knew it was sensible to wear a mask.

Who knows? - we would need to find out. Maybe that the critical abnormal process in ME is so hard to observe because it involves supramolecular solid phase changes within brain cells at a level that at present we have no means to observe directly?

That sounds an odd sort of job for a charity of this sort. Research directors work in academic units as a rule. Large charities do have people to supervise allocation of research funds but it isn't clear that this is what this job is.

I don't think anyone was saying that this SNP would account for most ME. I see it as a bit like C1q deficiency, which accounts for a tiny proportion of cases of lupus but provides a hugely powerful piece of evidence for the importance of complement in the genesis of lupus. It turns out that...

It almost certainly is. However, since the NHS at present couldn't implement an extended session of imbibition of alcohol in a fermentation plant I cannot see the point of any of that verbiage.

I had no message about confidentiality.

There is bound to be a way to fit it in but the question is whether it adds a further 'aha' to the story. I am a bit preoccupied with other things today but will come back to this. It is only a speculation but it has some theoretical attractions.