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All those poor anchovies, tons of them, plus other sentient beings. There will be a better way (research leading to a pharmaceutical) to deal with Alzheimers without decimating further the fish population.

Second author affiliation is with: Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang which leads me to doubt--could there be some political tainting of the...

More on ketamine, perhaps inappropriate use in France in outpatient, non-palliative pain care uses, including FM. https://www.storkapp.me/paper/showPaper.php?id=967460353&displayKey=K63QTkhbwI

Could get out my cane and practice fencing thrusts whilst on the street, should it get too crowded.

Yesterday they lifted the mask mandate in California except for one county. This means not too much for me, except that I need to have even more patience before I can get my overdue Shingrix shot at the local pharmacy, or traipse into a grocery store for some beloved item that the delivery...

I like the DEA (US Department of Drug Enforcement, serious drug police) version of what ketamine is all about: https://www.dea.gov/sites/default/files/2020-06/Ketamine-2020_1.pdf

Strange to use a Proof of Concept trial for a drug that is already on the market. Maybe is a code word for a small study without a lot of statistical power. However, here's a link to a citation given by the study above for a RCT using bi-polar patients, who had significantly less fatigue than...

From Wikipedia, the only reference to increased energy: "Ketamine appears not to produce sedation or anaesthesia in snails. Instead, it appears to have an excitatory effect.[151]"

Part of the exclusions for becoming a test subject in this trial: "4. Current or past psychiatric disorders including medically documented depression with psychosis, bipolar disorder, schizophrenia; 5. Clinically documented post-traumatic stress syndrome and/or traumatic brain injury because...

Are the researchers merely using anger scans because they have them in their possession and found an inverse link? After all, they are affliated with the Veteran's Hospital in LA, where plenty of veterans have PTSD from various wars the US prosecuted. Typically PTSD in veterans is associated...

yeah but, have a neighbor w/lingering covid (three weeks or so) and she cannot not do strenuous yard work all day. Maybe she takes a med that makes her that way, who knows, for depression, or maybe anxiety makes one that way. She told me she cannot sit still and yet suffers from covid...

From what I know about FM and all the reading about it I've done because I have it, these are the prime risk factors: female sex middle-age diagnosis of rheumatologic disorder

Researcher Straud is a long known FM guy. Seems (fMRI) an expensive tool or way to "provide a new method for the evaluation of chronic pain/fatigue mechanism and their response to therapy."

Exactly, @Trish. I remember when that term was born--read about it in coursework for nursing or psych or medical in general. It sounded right and good. Concepts drift (to the lowest common denominator-brain) and pick up all flotsam on their journey. Time for this one to dock permanently and be...

No, I don't think the Centrality of Pain Scale or COPS refers to any central sensitization--neuro-type category. It is a psych scale of how 'central' the chronic pain is to the person's life, as @rvallee just now pointed out. My guess is we'll be seeing more about this instrument, the COPS...

Uh...sounds highly improbable.

I'd really like to increase my activity level with FM. I overdid it recently and had a bad 3-day muscle spasm that spread to half of one leg. I took so much muscle relaxant (and its efficacy wasn't great) that I developed constipation. (this is now the 4th day of gas pains). What is evident to...

Thank you @Jonathan Edwards for that.

A review below about the descending pathway of pain modulation by dopamine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057207/ From the review just above, these quotes: "However, a recent study reported that although dopamine appears to affect expectations and desires, dopamine changes in...

The lead researcher is from the University of Zurich, department of psychiatry and psychosomatic medicine. Need I say more? I read parts of the study and was incensed by the theory that we with fibro are not motivated (the dopamine deficit theory). I have been suffering a three-day (so far)...