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Given these results though. It sounds like the main effect was that: “people with Long COVID (without PEM) who exercise tend to improve exertional capacity” And not “people with Long COVID (without PEM) have an improvement in their illness due to exercise”. Because the main improvement not...

And it’s a randomised controlled trial? And objective primary outcome measures? That’s probably the best methodology I’ve seen on a Rehabilitation study yet.

It seems cytotoxicity (the ability of a stressor to damage cells) can be a phenomenon that is delayed in comparison to the original stimulus. Ie. it seems depending on the immune or chemical leading to cytotoxicity it can occur instantaneously to a week after. [1] It seems also a well regarded...

Also do note that the author of this paper isn’t very ME informed. ie. https://www.cell.com/trends/neurosciences/abstract/S0166-2236(13)00196-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223613001963%3Fshowall%3Dtrue

If we knew, we probably wouldn’t be here. In my opinion given the lack of findings, it’s probably related to a complex mix of factors which are very hard to understand from a human POV, and machine learning with large data samples is likelier to make sense of it.

Abstract: Current research into mood disorders indicates that circulating immune mediators participating in the pathophysiology of chronic somatic disorders have potent influences on brain function. This paradigm has brought to the fore the use of anti-inflammatory therapies as adjunctive to...

Aswell as this potentially being relevant to ME/CFS, because one theory is that the body is stuck in a persistent “sickness response” loop following physical trauma, this is particularly interesting given the metabolic problems found in ME “Interestingly, many alterations associated with...

Abstract: Everyone knows that an infection can make you feel sick. Although we perceive infection-induced changes in metabolism as a pathology, they are a part of a carefully regulated process that depends on tissue-specific interactions between the immune system and organs involved in the...

So do I. I feel a possible hypothesis is that there is a negative feedback loop somewhere in the sickness response of pwME which leads the body to dysregulate itself in all sorts of ways possibly never managing to completely leave the “sickness response” state. Many of which might contribute as...

Abstract: Sufficient evidence is now available to accept the concept that the brain recognizes cytokines as molecular signals of sickness. Clarifying the way the brain processes information generated by the innate immune system is accompanied by a progressive elucidation of the cellular and...

“These effects [physiological response to acute infection] result in decreased muscle and aerobic performance, the full recovery of which may require several weeks to months following week-long febrile infections.”

Abstract: Acute infections are associated with multiple host responses that are triggered by cytokines and correlated to fever, malaise and anorexia. The purpose of this systemic acute phase host reaction („the acute phase response”) is to mobilize nutrients for the increased needs of the...

Abstract: Exertional fatigue, defined as the overwhelming and debilitating sense of sustained exhaustion that impacts the ability to perform activities of daily living, is highly prevalent in chronic kidney disease (CKD) and end-stage renal disease (ESRD). Subjective reports of exertional...

You just taught me something new today, thanks! I imagined if it didn’t work with the “edit” function it wouldn’t work at all.

Completely forgot to add the year (2024) to the title. Doesn’t seem I have permissions to change the title though.

Abstract: The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks1,2,3. These dynamic regulatory circuits that respond to extracellular cues in primary human cells remain poorly defined. The...

To add to this, a severely ill person who has been treated like this will inevitably develop massive trauma, and a distrust for the medical system, which in a sense is a self fulfilling prophecy, making it all the easier to blame on “irrationality” and “psychiatric problems”.

I think that may be part of the rationale. It’s definitely convenient and easy to simply ignore severe people. And it’s still being done, from the majority of research to the majority of news articles to even a large chunk of advocacy. A large majority simply do not understand what severe ME is...

I don’t think so. I can recall the transcript of a conference he went too where there were nearly only psychsomatisers and he spent his whole speech and Q&A pushing back against them.