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Abstract: This study aimed to identify signalling and metabolic pathways significantly impacted by alterations in cytokine and metabolic levels in response to acute cold exposure (CWI) following rest and exercise. In line with some previous studies, acute exposure to cold and exercise...

Abstract: The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of the hemostatic and complement systems has been...

I almost feel we need to distinguish between two bits of PEM. PESE which is the worsening or triggering of symptoms, I wouldn’t be surprised if this also happens in various other diseases. PEBD? (post exertional baseline deterioration)? which is that “crash” where you have limited capacity do...

Coq10 gives me absolutely nothing. I cannot tell at all a difference between taking it and not. And my blood tests show very low levels.

This seems to be a pretty good argument in Solve ME’s favour

I think it was some stem-cell thing, the therapy being basically to stick the cells from your right arm into your left arm, which is an alt med treatment kind of thing that says it will cure 100 things but has RCTs showing it works for none. I’m possibly imaginging or misremembering this...

Simmaron does look quite interesting. I somehow had mixed them and polybio up in my head.

Incase anyone stumbles upon this in 2024 or later, the ME Association has had significant controversies recently and I wouldn’t recommend donating at this time. See thread

See Also: Which ME/CFS charity would you donate to right now for biomedical research? And: What are the best UK charities for ME? Following my receipt of a 50 USD charity gift card in a giveaway which only works with US Charities, I am left wondering what charity to spend it on. In the list of...

Fascinating. Note that the doses used commonly for apiprazole (5-30mg) and therefore likely what this study is referring to are quite different than the dose some ME patients report improvement from which is more like 0.1mg-4mg.

Abstract: Hepatic encephalopathy, defined as neuropsychiatric dysfunction secondary to liver disease, is a frequent decompensating event in cirrhosis. Its clinical impact is highlighted by a notable increase in patient mortality rates and a concomitant reduction in overall quality of life...

Yes. Ever been to a doctor and they can’t figure out what’s wrong with you, two things will be said. 1) Make sure to eat properly and exercise and reduce stress 2) Are you often anxious/stressed/depressed?

Abstract: COVID-19, a highly infectious disease, caused a worldwide pandemic in early 2020. According to the World Health Organization (WHO), COVID-19 has resulted in approximately 774 million cases and around 7 million deaths. The effects of COVID-19 are well known; however, there is a lack of...

Now 13’650 signatures

I sincerely hope you’re wrong. But a part of me knows you’re right.

It actually seems okay given the description but this part is a massive facepalm Like hello tens of thousands literally developed extremely typical ME from COVID?

Arte which is the most popular channel to watch documentaries on in France, has made an ME/CFS documentary (I think Arte is also popular in Germany). I’m not able to watch and haven’t seen anyone mention it so I don’t know if it’s any good. But it’s a pretty big thing that Arte made one I...

I vaguely remember Ron Davis saying he used it to teach at stanford too but perhaps my memory is fuzzy.

Hahaha I did see a couple on there but the vast majority of the new signees are from the MEA newsletter I think.

It feels to me one of the largest problems in medicine is a lack of humility. It seems exceedingly rare to hear “we don’t know”.