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There is though the possibility that one latent or integrated pathogen is reinvigorated (sorry, I can't think of the right term) when someone is battling one of many possible infections (or even some other stressor). So, perhaps a herpes virus that most people acquire in childhood, or a HERV...

Yes, that was mentioned in the media item I saw. A brain tumour had been suspected, he had scans and nothing was found. Link to an article about the rugby player, Billy Guyton. The article says that tau proteins are markers of the damage. In that case, there are ways to test the living brain...

Thread on the symposium where the NIH investigators presented their findings 2024: NIH National Institutes of Health - ME/CFS Symposium on Intramural study - 2 May (There are links to other threads related to the NIH ME/CFS Intramural study in the first post of this thread.)

To keep this thread focused on news items, we have split the posts about the NIH Post-infectious Study off to this thread: 2024: NIH National Institutes of Health - ME/CFS Symposium on Intramural study - 2 May

In the closing credits of that Walitt video is "DISCLOSURES Dr. Walitt has no financial conflicts with industry." Which is a strange way to state things. It makes it sound as though he is financially aligned with industry. I didn't realise that he is a physician. The thought of him treating...

Oh, there's no expectation of us deluded souls fixing ourselves. That's what the professionals are for. I'm sure there are platoons of nice ladies with blue cardigans standing by to follow a manual written by Walitt, White et al, to cure us of our lack of self-awareness and faulty effort...

Yes, and it's important to also consider the consequences of that 'worthless nonsense'. It's one thing to produce worthless nonsense, lots of people do that a lot of the time. But it's quite another for that worthless nonsense to direct the thinking of arguably the most significant funder of...

Coincidentally, I have just posted an older study that reported on NK cell numbers and cytotoxicity before during and after exercise. There appears to be variation in how individuals respond to a particular exercise event. Flow Cytometric Analysis of Natural Killer Cell Lytic Activity in Human...

It's yet another study with small numbers in the groups. We have discussed the difficulty of characterising NK cell function before. Blood samples were collected from many places, with a full blood count completed within 4 hours at labs that are not NCNED. But, the authors do not say how long...

I thought this was an interesting read for a couple of reasons. One is the information about how to determine the cytotoxicity of natural killer cells. There's been a long history of dispute about whether there is something wrong with NK cell function in ME/CFS. These authors say that the...

Link to paper Abstract NK cell cytotoxicity is a widely used measure to determine the effect of outside intervention on NK cell function. However, the accuracy and reproducibility of this assay can be considered unstable, either because of user's errors or because of the sensitivity of NK...

A few asides before I read past the introduction (ignore if you aren't in the mood for pedantry) I do not like that definition. We've discussed 'complex' and 'multisystemic' before - neither are very helpful and 'complex' often leaves the door wide open for a psychological contribution to...

Yes and one of the related participants reported developing Long Covid after the first visit. Of course we don't know how if she was one of the 'healthy controls' who was recorded as having POTS, but there may have been some confounding with relatives used as controls.

From the 'Did Army Blast Exposure Play Role in Maine Gunman's Rampage?' - an interesting read, thanks @Gradzy In NZ there has recently been the case of a rugby player who suffered many concussions in his life. He became psychotic and violent and took his own life. An autopsy confirmed brain...

NIH director of intramural research - brief comment All the complexities require a team approach. A disorder that involves the immune system, microbiome, autonomic nervous system... Partnership with patients and advocates and universities and industry are critical. Grateful to everyone who has...

Nath - future directions There can be missed diagnoses, so it's really important to closely follow them to discover if there is an underlying disease (I assume he means aside from ME/CFS). They learn that people with ME/CFS can spontaneously recover. The nervous system does play a critical...

Lipkin was surprised about the lack of difference in tilt test findings. (I forgot to say that the healthy control (a sister of a ME/CFS participant) who spoke actually developed Long Covid after attending the NIH first visit.) He found the findings on catecholamines were really interesting...

Panel: Komaroff moderating. Klimas, Lipkin, Vicky Whittemore, Joe Breen Komaroff says that there have been a lot of papers documenting biological abnormalities. He suggests that this study finds that ME/CFS is a brain disease caused by immune exhaustion. Mentioned the Time 100 in Health - 4...

One of the participants told us about her experience and it sounded really really difficult. It was clearly a huge effort and I am grateful. She said several times that Brian Walitt had been very caring. Of course, someone can be very caring while regarding the people they are caring for as...

Walitt on open science: Walitt bleating about how much it costs to make a publication open access and how good they are that they spent the money to make the paper open access. Open access to data They will be doing more work on the data.