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Now published in Nature Scientific Reports as Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19. There's substantial changes when compared to the 3 year older preprint.

Now published as 3D Holo-tomographic Mapping of COVID-19 Microclots in Blood to Assess Disease Severity.

I agree that those things could all be considered wins and these things happening is certainly better than them not happening, but those wins don't mean anything is changing, they might just be temporary effects that are irrelevant in the grand scheme of things. It's possible that things will...

Cohort Follow-up of 113 hospitalised Covid-19 patients for 1 year (measurements taken at 0, 6 and 12 months). Thus according to most studies one would expect roughly 5-15 of these to develop LC with maybe 0-2 having severely disabling LC. However, one third of this cohort also had a severe...

Is this a LC study or a PICS study? Does CBT have any merit in PICS?

One-year follow-up of young people with ME/CFS following infectious mononucleosis by Epstein-Barr virus Background: Infectious mononucleosis after primary infection with Epstein-Barr virus (EBV-IM) has been linked to the development of myalgic encephalomyelitis/chronic fatigue-syndrome (ME/CFS)...

In his defence Twitter can be a very aggressive medium, where harassment is a very close cousin to justified criticism. I suppose there might be better places to discuss such things than social media (email often seems more fruitful).

Now available as Prepublication Release in AAP Pediatrics as Vaccine Effectiveness Against Long COVID in Children.

Amantadine (Gocovri) is used in the treatment of Parkinson, albeit its mechanism of action is poorly understood, and is used as an antiviral in influenza caused by type A influenzavirus. It acts as a nicotinic antagonist, dopamine agonist, and noncompetitive NMDA antagonist. The basis for this...

A randomized open-label clinical trial on the effect of Amantadine on post Covid 19 fatigue Abstract Many COVID-19 survivors experience lingering post-COVID-19 symptoms, notably chronic fatigue persisting for months after the acute phase. Despite its prevalence, limited research has explored...

The study has now been published in Cell Reports Medicine as Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation.

I agree that social media is bad for discussing anything research related and shouldn't really be used for that. I was more so proprosing to contact him (or one of the patient representatives) via email.

I also suspect following the discussion might be somewhat confusion if one isn't used to S4ME, because the discussion is already 8 pages long. Indeed they are, to some extent, collaborating with Pretorius as well as Fluge/Mella (see also...

Of course the small sample size and lack of controls makes it impossible to say too much about these results. Maybe this can be followed-up by a larger and controlled study, but if that was worth it they probably would have gone for such a study straightaway. What I definitely learnt: I never...

This is absolutely horrendously bad epidemiological modelling for people who don't understand any basic mathematics. Apply this principle to any virus and humans would have been extinct centuries ago, but of course they aren't because this model is absolute crap (hard to even call it a model)...

This data includes vaccine effectiveness (LC rate among all people). Their data suggests that the vaccines had a tremendous impact at preventing a Covid-19 infection altogether (roughly 3.5 times better odds at not getting infected), at a larger rate than what I have seen in more rigorous...

Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naÏve individuals with Long COVID Abstract Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and...

You might enjoy this thread @Simon M where some users are expressing their understanding of the "PEM" nomenclature. My impression is still that we often know how PEM feels but that, that is something that hasn't sufficiently been understood or investigated (very similar to how the brain...

I'm not too sure there's any information on how the bland non-hospitalised data can be interpreted (I'm guessing there could be some other factors as well, maybe some questionnaires/methods nowadays viewed as standard were only ever standardised by testing them on males?) Another possible...