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We don't and we can't. Virtually everybody has had Covid, this research will never be causal and at best it will detect some correlations that might not be noise. That'll only change if dementia research can ever unlock some more useful markers. So if the findings hold water you will see a...

Temporal Association between COVID-19 Infection and Subsequent New-Onset Dementia in Older Adults: A Systematic Review and Meta-Analysis Abstract Background: The relationship between COVID-19 infection and the increased likelihood of older adults developing new-onset dementia (NOD) remains...

Posted because it seemed "fancy" to a layman like me. It doesn't have any relevance to ME/CFS as far as I can tell (quite the opposite). Ankylosing spondylitis is an inflammatory T cell disease and is majorly driven by genetics. In fact the association to HLA-B27 is so strong that it’s even...

Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis Abstract Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail...

A phase 2a open-label clinical trial to determine the effect of famciclovir on EBV activity as measured by EBV shedding in the saliva of patients with multiple sclerosis Abstract Background: Despite increasing evidence that Epstein–Barr virus (EBV) plays a causal role in MS, no treatments have...

Rob Wüst (Appelman et al) has said on Twitter that he can neither meaningfully interpret the study results (including the earlier ones of Scheibenbogen) nor that he is able to compare them to the results to his study. www.twitter.com/RobWust/status/1755111198096245100

A significant problem with this study could be that This algorithm is discussed here. It's currently established that Fluvoxamine does nothing for acute Covid-19 as there have been multiple RCTs on this subject, which is probably a good thing for their study as the severity confounder of the...

I'm afraid the problem with smart watches is that they are typically very inaccurate as they are lifestyle devices rather than anything else. Some of the fitness devices are better and are sometimes highly accurate in measuring certain things but completely inaccurate in measuring others. So if...

People have asked for further information. Thus far there haven't been responses that haven't been extremely vague. I believe this mainly has to do with this being run by patients who have no background in organising or attending scientific conferences and don't have a research background but...

Apart from showing strength in numbers does the petition have another value, as in a certain threshold of signatures crossed amounts to something? I was also wandering about the significance of the website petities.nl, is just a dutch version of something like change.org or or does it have more...

Can the Hospital Episode Statistics data be re-analysed to estimate the prevalence of different autoimmune diseases (or other conditions, Scheibenbogen claims Raynauds is more prevalent in ME/CFS patients) amongst those patients compared to the general population (a priori, to me, it might not...

I just saw another press release. I cannot judge the quality of their argument or how much of a problem it would be, but in this press release the authors propose that “Every cell in a woman’s body produces Xist. But for several decades, we’ve used a male cell line as the standard of reference...

I couldn't tell you as I don't have a medical background. All I can tell is that there seems to be a divide amongst autoimmunity researchers with one side of the group thinking "T-cells are everything" and many diseases, such as Type 1 Diabetes, Multiple Sclerosis, APSs, seemingly being widely...

Would that reasoning also apply to autoimmune diseases that many commonly classify as primarily T cell mediated?

The article is about this work Xist ribonucleoproteins promote female sex-biased autoimmunity. The paper hasn't been published yet, but will appear later today in Cell (the above preprint has been available for 1.5 years, so it's probably not spectular news for those working in this field).

I think the problem as Trish says is that we don't know anything about which disagreement this is referring to. Is it the useless and often typically attacking and harassing "LC vs ME" debate that has been constructed by some people on Twitter which you are refering to, is it the Dragons’ Den...

Haven’t looked into it, but from what you are saying it could indeed look interesting to me. It seems they “evaluate” many of the things that are also popular in ME/CFS communities (for example Fecal Transplants) so I a priori don’t think it should be an impossible task just because too little...

Artur Fedorowksi has replied to the response "Graded exercise therapy should not be recommended for patients with post-exertional malaise". I think this makes his position very clear. Of course he has no problem contradicting himself here since if there's no verdict he shouldn't have recommended...

There was a small RCT Fampridine for LC that was recently completed (results still outstanding). Fampridine is 4-Aminopyridine, whilst Amifampridine is 3,4-Diaminopyridine (not that I'd understand what that actually means but here are their chemical structures). It seems Fampridine was initially...

Reduced Fatigue Symptoms in the Post-COVID Syndrome With Amifampridine: A Collective Casuistry With Double-Blind Discontinuation Trials Abstract After a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, approximately 10-20% of patients are affected by the post-COVID...