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Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic immune activation. Whether persistent pathobiont colonization during immune alterations and...

It appears that this is the study vanElzakker (which is the study mentioned above by @Andy) was referring to (see also www.twitter.com/MBVanElzakker/status/1487878902651527172)

Does anybody know what happened to the Stanford study of Prof. James that was also using a PET scan to tag TSPO in ME/CFS patients? Were there negative results that weren't deemed useful to be published? An older thread is here...

I can definitely see this being true, especially as it seems that many people, including me, weren't aware of such a study for ME in the first place (recruitment appears to still be open www.twitter.com/MBVanElzakker/status/1715765815717335210). Several Long-Covid studies and trials are...

The article is a opinion piece to have a central piece of writing to address politics in the hope of receiving much needed funding. I think it's extremely hard to judge which way to address politicians is the most effective way. Mention ME/CFS in an appropriate fashion and politicians and...

A Twitter thread summarizing different talks, which should be uploaded to the website soon.

Evidence of autoinflammation as a principal mechanism of myocardial injury in SARS-CoV-2 PCR-positive medical examiner cases Background Disease from Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) remains the seventh leading cause of death in the United States. Many patients...

Association Between Guillain-Barré Syndrome and COVID-19 Infection and Vaccination: A Population-Based Nested Case-Control Study Background and Objectives: Existing data regarding occurrence of Guillain-Barré syndrome (GBS) following COVID-19 infection and vaccination are inconclusive. We...

SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration Introduction Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) affects extra-respiratory systems, with small-scale studies showing worsened male lower urinary tract symptoms (LUTS) after coronavirus...

Sounds interesting, thanks for sharing. Let’s see what the paper will really entail (scientific news reports are of course highly unreliable and very clickbaity). I couldn’t find a google scholar account, but Thomas Berger has a ResearchGate account...

That's what the most of us are wondering about as well, I believe. It seems they are trying to somehow address the reduced vagal function, which they of course can't measure in a trial, and memory impairment, but of course we are more complex than a simple mice model of an acute infection...

I guess "Tik Tok Biotic" has a ring to it. And since no medical assessment or even a diagnosis is required to participate you can always end up claming anything, present whatever data snippets you want and for any non-improvements "you didn't do the complete protocol" or "our protocol is now...

These were my exact first thoughts as well. The second thing is that the idea behind the paper is somewhere along the lines of "what goes wrong in those with a very severe actue infection could be similar to what is happening in LC on a permanent basis". If that is the case there has to be an...

I don't dismiss the Iwasaki study or B cells at all, that's why I posted it. However, “numerous data points showing increased b cell activity” and “there are so many high quality studies its bursting out my ears” is very different to me than having less than a handful of extremely noisy studies...

Could you please post some of these studies that find some vast B-cell differences in LC patients? I have been following the research very intently and I'm pretty sure that almost every study on LC has been posted on this forum and to me the B cell data often looks quite noisy, or at least it is...

Quite a big study with a ton of authors, many of which are well known in the Long-Covid field. The study is already being covered by the big news outlets in America. https://www.nytimes.com/2023/10/16/health/long-covid-serotonin.html...

Serotonin reduction in post-acute sequelae of viral infection Highlights Long COVID is associated with reduced circulating serotonin levels Serotonin depletion is driven by viral RNA-induced type I interferons (IFNs) IFNs reduce serotonin through diminished tryptophan uptake and...

I can completely understand why many researchers are currently focusing more on going after a persistent SARS-COV-2 virus rather than something like EBV. First of all there are actually mAbs for SARS-COV-2 as well as many different antivirals, with different mAbs and antivirals being in...

Neurologic Effects of SARS-CoV-2 Transmitted among Dogs Abstract SARS-CoV-2 induces illness and death in humans by causing systemic infections. Evidence suggests that SARS-CoV-2 can induce brain pathology in humans and other hosts. In this study, we used a canine transmission model to examine...

Thanks, but I'm not sure if that does answer the question, I think I just know too little about the subject. For homosexuality being viewed as psychological disorder and then treated with "conversion therapy" very similar beliefs were present and there is a Freud connection as well as a...