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Abstract Ehlers–Danlos syndromes (EDS) are a group of connective tissue disorders caused by mutations in collagen and collagen-interacting genes. We delineate a novel form of EDS with vascular features through clinical and histopathological phenotyping and genetic studies of a three-generation...

"The Bill & Melinda Gates Foundation, one of the world’s top biomedical research funders, will from next year require grant holders to make their research publicly available as preprints, articles that haven’t yet been accepted by a journal or gone through peer review. The foundation also said...

Yet it probably won't. The FND researchers will just point at this sort of research, proclaiming 'See, FND is actually a thing, these results prove it!', despite years of advocating for the smallest amount of investigation that can be got away with.

Abstract Objective The role of inflammation and neuroimmune mechanisms, which have been documented in various neuropsychiatric disorders including the seizure subtype of functional neurological disorder, remains unclear in functional movement disorders (FMD). To explore these mechanisms, we...

Abstract Ewing sarcoma is the second most frequent primary bone tumour of childhood and adolescence. The aim of this report is to describe the imaging, pathology, clinical findings, and treatment of a primary intradural extramedullary Ewing sarcoma with a unique intracranial metastatic...

We believe that, unless the planned programming changes, Channel 4 news will have another section on ME/CFS tonight which will, in part, include reporting on DecodeME.

Trial By Error: Yet Another Long Covid Study with Bogus Claims Published by a Prestige Journal "I’ve recently spent some time lambasting a Long Covid study in The BMJ that claimed a rehab program addressing both physical and mental health was “clinically effective”—even though the primary...

Abstract Mast cells (MCs) are known to have a pathological impact in a variety of settings, in particular in allergic conditions. There is also limited evidence implicating MCs in diabetes, raising the possibility that MC function may be influenced by alterations in glucose levels. However, it...

The existence of this scheme was highlighted on Twitter again yesterday.

Abstract Background Chronic Fatigue Syndrome patients suffer from symptoms that cannot be explained by a single underlying biological cause. It is sometimes claimed that these symptoms are a manifestation of a disrupted autonomic nervous system. Prior works studying this claim from the complex...

Abstract Mental fatigue is common in society, but its effects on force production capacities remain unclear. This study aimed to investigate the impact of mental fatigue on maximal force production, rate of force development-scaling factor (RFD-SF), and force steadiness during handgrip...

Highlights Lactate monitoring has the potential to extend beyond applied sports settings and could be used to monitor the physiologic and pathophysiological responses to external and internal stimuli in chronic disease areas such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)...

Fukuda criteria used for "CFS" patients. "CFS is a clinical diagnosis of exclusion, where other somatic and psychiatric illnesses must be ruled out as the cause of symptoms. It is characterized by pronounced fatigue and reduced functioning. The condition must have persisted for six months or...

Abstract Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS, characterized by post-exercise malaise (PEM), is a severe multisystemic disease for which...

Monthly News in Brief post on Reddit. https://www.reddit.com/r/cfs/comments/1bszanl/news_in_brief_posts_for_march_2024_covering_mecfs/

Published papers thread for w/c 25th March Facebook: https://www.facebook.com/sci4me/posts/pfbid02q3wJFBAaeE2uozdromVi7wDLtfjjC45XUvPkiT3XVvwgRGxi5eSUyGuqJaGGPtxVl Mastodon: https://med-mastodon.com/@s4me/112195241806071424

Abstract Background Ultra-trail running races pose appreciable physiological challenges, particularly for glucose metabolism. Previous studies that yielded divergent results only measured glycaemia at isolated times. Objectives We aimed to explore the impact of an ultra-endurance race on...

I haven't heard from the MEA for 30 days now. They would seem to be happy for people that they fund to be abusive towards members of the patient community that they claim to represent.

News in Brief post for w/c 25th March. Facebook: https://www.facebook.com/sci4me/posts/pfbid02HPgEu3moMhF5BAUVvrdK45etiFQSdMSghcG6iu4vQHrXEMS4E3YAnqfgufpzNnhHl Mastodon: https://med-mastodon.com/@s4me/112189475230736269

Why it's important that PEM is not fatigue https://mecfs.substack.com/p/why-its-important-that-pem-is-not