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Abstract The contemporary neuroscience understanding of the brain as an active inference organ supports that our conscious experiences, including sensorimotor perceptions, depend on the integration of probabilistic predictions with incoming sensory input across hierarchically organized levels...

Full title: Associations between brain morphology, inflammatory markers and symptoms of fatigue, depression or anxiety in active and remitted Crohn’s disease Abstract Background Fatigue and psychosocial impairments are highly prevalent in IBD, especially during active disease. Disturbed...

"Chronic fatigue syndrome (CFS) In contrast to the previously discussed syndromes, only a few studies address a possible link between indoor dampness/mold exposure and CFS [24, 214, 662]. Here, too, is assumed that CFS etiologically has multifactorial genesis with biological, social and...

Abstract Background This study investigates the impact of fluctuating lipid levels on endothelial dysfunction. Methods Human aortic and umbilical vein endothelial cells were cultured under varying palmitic acid (PA) concentrations: 0, 50, and 100 μM, and in a variability group alternating...

From the DecodeME FAQ, https://www.decodeme.org.uk/faqs/are-you-looking-for-a-family-genetic-link/ "There is evidence of a genetic link in ME/CFS and people with close family members who all have the disease. We aren’t looking into specific family groups in this study, although our analysis may...

From the transcript of the most recent DecodeME webinar, https://www.decodeme.org.uk/webinar-recording-and-transcript-march-2024/ "we are collaborating with Hanna Ollila and Anniina Tervi from FinnGen, in Finland, who already are analysing ME data from electronic health records from different...

"The proposed study will be a three-arm randomized clinical trial (RCT) of PCC patients diagnosed with ME/CFS according to WHO working group criteria1" Reference given is to WHO: A clinical case definition of post COVID-19 condition by a Delphi consensus "The sample size was calculated using...

Full title: Comparing effectiveness of physiotherapy versus drug management on fatigue, physical functioning, and episodic disability for myalgic encephalomyelitis in post-COVID-19 condition: a study protocol of randomized control trial Abstract Background Physiotherapy interventions...

‘It’s destroyed us’: Parents of children with long Covid accused of making it up "Parents of children with long Covid claim they have been accused of faking or exaggerating their child’s illness, leading to social services’ involvement and, in some instances, court cases and the threat of the...

In order to detect the presence of HHV6, Glasgow Uni needed physical samples to test. A lot of the DNA samples have had material left over after sufficient is taken to sequence the DNA - we were able to ship this leftover material, where participants had given us permission to share with other...

Pre-recording of the DecodeME presentation to be delivered at BACME conference on 16 May 2024

I've created a new thread for this new study, Uni of Glasgow: Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) in DecodeME [Analysis completion planned for end of Sept 2024]

This is a study making use of samples collected by DecodeME, where participants agreed that samples could be shared with other researchers. Summary - REQ001 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two, closely related viruses that infect humans. We often refer to them collectively...

$27,533 raised, 42% of total, 15 days left. https://crowdfund.berkeley.edu/project/42302

My take is that all the other symptoms are bad enough, but what adds additional disability is PEM. I either overexert myself in trying to overcome, however temporarily, the restrictions put on me by the other symptoms and trigger PEM and have my low functioning level forcibly reduced, or I limit...

‘I’m fighting for the right to live’: Liz Carr on acting, friendship and her campaign against assisted dying "Surely, though, assisted dying is about personal choice? Even if legislation were brought in and included “unbearable suffering”, which might make someone with Carr’s condition...

Poor maternity tolerated as normal, inquiry says An inquiry into traumatic childbirths has called for an overhaul of the UK's maternity and postnatal care after finding poor care is "all-too-frequently tolerated as normal". The Birth Trauma Inquiry heard harrowing evidence from more than 1,300...

Highlights A conservative strategy favoring accuracy was adopted during a cognitive task that induced mental fatigue Mental fatigue during a cognitive task leads to a decrease in sympathetic activity with increasing time-on task Mental fatigue induced by a 30-min effortful cognitive task...

Published papers thread for w/c 6th May Facebook: https://www.facebook.com/sci4me/posts/pfbid02KjLi9AcdFHEbipxuNiTWppaUf6ikJ6K3VbZ9tQHbiuiSzvgUtrbqrqx44KKt3ptWl Mastodon: https://med-mastodon.com/@s4me/112432670820840047

Abstract Background Psychological interventions are a promising area for fatigue management in patients with inflammatory bowel disease (IBD). However, most interventions trialled to date have been pilots with limited direct input from patients about the type of intervention they want. Thus...