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Both. I think he first took Ativan, after which he improved, and then Abilify, which seemed to help more. But I think some of the effects wore off eventually. This seems possible, given the numbers of different compounds involved. Of course, they could also end up making people worse.

I was surprised at the reaction to that. I had no idea Muppets meant anything other than the actual puppet muppets. In US, as far as I know, it is not used in the same slang way.

and when did "symptom-based disorders" become the term? It's better than previous efforts, I guess--on its face, it doesn't automatically imply "psychosomatic"?

In his comment, Chris Burton references his own trial of persistent physical symptoms, published in The Lancet, to indicate that "we can make a difference." But that trial had primary outcome results that were below the minimal clinically important threshold for the metric, as Joan Crawford and...

I haven't read them but it sounds like they both accept the biopsychosocial framing and the need for these services, and essentially are just arguing about whether the NHS is implementing this approach effectively or not. And yes, I'd heard you were being interviewed for Adam. How'd it go??? :)

Oops!!! Never mind!

and they're making causal statements despite lack of a comparison group.

Doesn't everyone just shove the shirts into the drawer without folding them, like me???

https://virology.ws/2025/12/11/trial-by-error-in-protocol-for-long-covid-exercise-trial-investigators-advocate-lying-to-participants/

I'm confused--is this different from the Lancet Neurology report they published on this trial alst year? https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00135-2/fulltext

But in this case it seems they're being told it's "standard" therapy when it's an experimental intervention, as far as I understand it. At least in the original design, if I've gotten this correctly, the people in the experimental arm are told they're undergoing an intervention that's being...

"Participants in both groups will be blinded to the intervention via the modified Zelen design (ie, will be informed that they are participating in an observational study followingthe natural progression of Long COVID and costs associated with standard treatments, then later debriefed)." This...

It seems to me that there are two separate issues here. Is UARS being undiagnosed/under-diagnosed, and does that mean that some or many people who might be helped by CPAP for their fatigue and other symptoms aren't getting it? It sounds like that might be going on. If so, that's obviously a...

I wrote a follow-up post. https://virology.ws/2025/11/25/trial-by-error-jama-touts-long-covid-exercise-trial-with-clinically-insignificant-results-most-lc-exercise-trials-ignore-pem-per-sick-times/

What is the significance of this??

maybe I'm biased, but I tend not to take MDPI journals that seriously. Even though I realize they publish some good papers by smart people. But whenever I see one of their papers, I instinctively recoil. ADDED: Am I wrong??

I focused on the MCID issue in this post: https://virology.ws/2025/11/21/trial-by-error-another-exercise-trial-with-clinically-insignificant-findings/

it's confusing, but that seems to be only among those found to have PEM. So in the intervention group, more of those with PEM at 3 months also have an ME/CFS diagnosis, while those with PEM in the usual care group are more likely not to have an ME/CFS diagnosis. Not sure what those data would...

exactly. they ignored it completely and just said essentially, well, we found some things that seem positive.

we recently discussed another study with some confusion over the MCID for the ISWT https://www.s4me.info/threads/post-hospitalisation-covid-19-rehabilitation-phosp-r-a-randomised-controlled-trial-of-exercise-based-rehabilitation-2025-daynes-et-al.42743/#post-591198 I mentioned the issues in...