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Hmm, I thought that the recent articles that I have read found that healthy controls had a decrease in cerebral blood flow of less than 10%, and the subjects with OI had a decrease of more than that. I don't remember reading about healthy controls having equivalent decreases, but perhaps I...

@EndME , the first (?) article describing POTS in what you might call the modern era was focused on idiopathic hypovolemia rather than orthostatic tachycardia as the hallmark of the condition (although the authors certainly also took note of the tachycardia). Idiopathic hypovolemia...

Article about CO rebreathing: Validation of a clinically applicable device for fast and accurate quantification of blood volume https://pmc.ncbi.nlm.nih.gov/articles/PMC10388222/ Note that one of the authors, Carsten Lundby, is from Detalo Health, the manufacturer of the device (this is...

Apologies. Have fixed this. Thank you for pointing it out.

This is why the 30BPM increase is only one part of the diagnostic criteria. The patient also has to be symptomatic: chronic OI symptoms of more than 3 or more than 6 months (varies between guidelines/authors). The selection criteria for Vanderbilt POTS studies are here (only in basic form)...

Complete guess on my part: The researchers included male controls even though there weren't any male subjects because they were interested in seeing the differences in the CO rebreathing and impedance data between the male and female controls and comparing the formulae for estimating blood...

I don't think there is any good data on the male/female make-up of POTS patients, but this survey (which obviously suffers from being a survey, and being in English only), found the following: Total valid survey participants = 4835 Female = 4539 (94%) Male = 296 (6%) Edited: Forgot to put...

It is touched on in the paper at several points – I am not scientifically literate enough to comment on what is said about it. They compare "female subjects to female controls" as well as "all subjects to all controls". Perhaps they did the best they could with the available patient population.

The researchers also used a technique called segmental body impedance, which I don't know much about. Would be interested to hear people's comments on it.

The device used in the study: https://detalo-health.com/ Carbon monoxide rebreathing is not a brand new testing method, has been used at NASA for instance, but I believe the "off the shelf" version being sold by this company is the first of its type. Research version, as used in above study...

Now published - link here Preprint Blood Volume Deficit in Postural Orthostatic Tachycardia Syndrome Assessed by Semi-Automated Carbon Monoxide Rebreathing Kulapatana, Urechie, Rigo, Mohr, Vance, Okamoto, Gambao, Shibao, Biaggioni, Furlan, Diedrich Abstract Purpose: Semi-automated carbon...

@Haveyoutriedyoga, thank you for the link. I asked my daughter and she did consider dumping syndrome a some years ago, but it was before we knew how to research things, or knew about forums such as ths one, so we will look into it again. Thank you for the suggestion.

A complicating factor is that she had her colon removed in her twenties due to ulcerative colitis, and she noticed after the surgery that this altered her perceptions of hunger. A physical example is that she no longer gets borborygmi (growling stomach) when hungry. She does do her best to eat...

My reason for asking is that since being unwell my daughter has been struggling with uncharacteristic irritable and even angry outbursts that follow a daily pattern and may be connected to meals. For instance, she says she recognised herself in this article...

Disclosure: Question relates to my daughter, who has been tentatively diagnosed with OCHOS, orthostatic cerebral hypoperfusion syndrome. I hope folks won't mind me asking a question for personal reasons. Assuming a reduction in blood flow to the brain of about 25% (average quoted in Peter...

Some of the questions raised in this thread are addressed in this video from the company: Sorry, it is a long video, and it was my daughter who watched it, so I can’t provide time stamps for every point. The bit about the external carotid artery is at 17 minutes in. The segments from Dr...

Also, I wonder whether there were any common findings between this study and this (much smaller) one on potential biomarkers in POTS https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/36414707/ I’m afraid I’m too tired to check. On heavy medications for pinched nerve. Thanks everyone and the...

I am interested in the SOd3 finding, but can’t quite follow the information in the article. Was it raised or lowered? And what might this mean? “Repeating this NDE analysis using the UKB 874 mediator on levels of 2,923 proteins, measured using antibody-based assays, yielded only a single...

So healthy controls could switch to a sort of automatic energy-saving mode to repeat similar tasks? That sounds handy for energy conservation, and the kind of shortcut brains employ a lot. I wonder whether the same inability to take advantage of this shortcut has been found in any other medical...

No, I was addressing two topics: one, that increased salt intake has been linked to health problems in the general population, and that that causes concern for people with orthostatic intolerance when their doctor suddenly tells them to eat more salt as opposed to the public health messages to...