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OSU 6162 is a partial D2 agonist similar to Abilify. Probably something here. Would like to see a longer study to see if tolerance/tachyphlaxis develops. https://en.m.wikipedia.org/wiki/OSU-6162

Silent no more...

Senior author https://en.m.wikipedia.org/wiki/Eric_Schadt

A lot of work just to make the visualization animations.

I’m waiting for my @Simon M explainer....Didn’t know that Mt.Sinai had a group working on this.

We’re druggable! Also too early in the process for them to cover Abilify. First I’ve heard of Myelophil. https://www.frontiersin.org/articles/10.3389/fphar.2019.00991/full

I support OMF—with many researchers and centers they are most likely to make a breakthrough.

Review article.

Moved post Whitney not sleeping well due to Abilify.

Not cheap. https://www.fiercepharma.com/sales-and-marketing/j-j-undercuts-celgene-s-pomalyst-135k-per-year-darzalex-price

https://www.insideedition.com/drew-pinsky-among-covid-19-long-haulers-with-lingering-symptoms-i-am-forced-to-lie-down-every-hour Drew Pinsky Among COVID-19 ‘Long Haulers’ With Lingering Symptoms: ‘I Am Forced to Lie Down Every Hour or Two'

Might be reversible somewhat. A bunch of us got a lot of relief from Abilify—Martin (paused_me) went from severe bedbound to going to work. I don’t think you would get a similar response in MS from any of their meds. I agree with the discussion of PEM. I’m not really much an acute PEM person...

I’ve mentioned this before but it would be helpful if OMF put out an official quarterly or biannual newsletter. Something short would be fine.

I have a feeling that OMF might be closing in on a biomarker. But if there is a biomarker and it reflects something downstream, is it possible that the biomarker might not be useful in identifying treatments? Are there examples of other diseases where a biomarker was found, but it was not...

Some discussion here about which meds Jay Goldstein predicted would likely result in tolerance in patients. https://forums.phoenixrising.me/threads/abilify-stanford-clinic-patients.62807/page-33#post-2309930

I am implanted and still alive!

Anyone have dental implants post ME/CFS? Did they heal OK? Just wondering if they heal properly if you are not very active or if you are horizontal for long periods of time. Thanks.

Re NYT article. I don’t know why Maureen Hansen was so stand-offish. If you meet the criteria for MECFS, then you have MECFS. Also unfortunate that Amy P was cited—no evidence for her theories. Also unfortunate that neither Ron Davis nor Robert Phair was cited in the article.

Better title would have been: COVID-19 Will Lead to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.