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Memantine similarly doesn’t do much for MS. https://www.frontiersin.org/articles/10.3389/fneur.2020.574748/full https://www.docwirenews.com/condition-center/multiple-sclerosis-knowledge-hub/memantine-does-not-improve-ms-fatigue/

https://onlinelibrary.wiley.com/doi/10.1002/acn3.51325 Interpretation NAC was well‐tolerated in progressive MS, although reduction in fatigue on NAC was similar to placebo. Antioxidant blood and MRS biomarkers were not significantly altered by NAC, which could be due to dose, route of...

Looks like a new phase was reported at a conference. Seems like you will need to be on this for life...or else you gain the weight back. Blockbuster drug for Novo Nordisk. https://www.healio.com/news/endocrinology/20210323/step-4-significant-weight-loss-maintained-with-weekly-semaglutide site...

Hopefully @Jonathan Edwards could comment on this study.

Yes....that guy

Good thread on this topic....

https://onlinelibrary.wiley.com/doi/10.1111/eci.13554 Abstract Background Estimates of community spread and infection fatality rate (IFR) of COVID‐19 have varied across studies. Efforts to synthesize the evidence reach seemingly discrepant conclusions. Methods Systematic evaluations of...

Mods have added a first post to provide the abstract and link and changed the thread title. Original thread title: Ioannidis ad-hominem attack paper Not MECFS, but indicative of the status of peer-reviewed journals. Or maybe none of the reviewers read the appendix.

Over 20,000 FDA approved meds. Hopefully something would work.... https://www.fda.gov/about-fda/fda-basics/fact-sheet-fda-glance

Thread from Ben H here

New update from Ron Davis—they are going to test all FDA approved drugs to see if they can overcome the metabolic trap using yeast cells.

That WSJ piece was bad, real bad.

Some people have had withdrawal issues and needed to restart Abilify to control symptoms (RLS) even though Abilify was no longer effective for MECFS. With psychotropic meds a lot of time the problems (akathisia/TD) are associated with withdrawal not with side effects while taking.

NY Times Long Covid Is Not Rare. It’s a Health Crisis. Wonder if @Jonathan Edwards could write a letter to the editor about this op-Ed stating that Long Covid is not a useful term since it incorporates several conditions and that post Covid people with MECFS symptoms most probably have MECFS.

https://www.researchgate.net/profile/Joshua_Leisk/publication/350043016_The_true_nature_of_an_autoimmune_disease/links/604d0d31a6fdcccfee7d03be/The-true-nature-of-an-autoimmune-disease.pdf?origin=publication_detail Preprint—not peer reviewed. Abstract Here we propose a hypothetical model...

J & J one and done—no probs at all.

Hi @Nixxy What dosage of DCA are you taking? Thank you.

Relevance to the MECFS metabolic trap theory?

This is the researcher he mentions https://chemistry.stanford.edu/people/chaitan-khosla https://web.stanford.edu/group/khosla/cgi-bin/

Looking for funding for Abilify study....