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21 subjects, with vague sets of factors (fatigue and diet), and they're trying to claim meaningful results? I expect if they redid this with completely random subjects, they could find some similar correlations, with the astonishing conclusions that one group was suffering from snake venom or...

I agree with your feelings about "thinking happy thoughts" is supposed to be such a great cure-all ... without reliable proof. Likewise about creating explanations without proof, which some people then hold onto fanatically. For ME, I feel that my 'think myself better' function is broken. How...

I think ME screws up neurological signalling, more or less at random, so having your satiation signals messed up seems plausible to me.

I see this as the sort of 'bit of knowledge' that might trigger a flash of insight in some other researcher. "Oh, that might explain why ...".

By 'it', I meant the connection between allergies and dietary fibre. If there was a significant correlation, I would have expected someone to notice that: "kids who eat fibre-rich foods are less likely to develop allergies than ones who eat a fibre-poor diet." If the correlation is minor, it...

Are there no ways to intentionally modulate this type of gene expression? Some drugs, cellular isolates, nutrients or whatever? I can imagine giving a test subject doses of various things, and one of them resulting in the patient saying "Wow, I feel healthy again." Even one that gives a...

Interesting, but if it's correct, I wonder why it didn't show up in statistical analysis of allergies. Maybe there are so many factors determining this process that preventing allergies won't be as simple as adding more dietary fibre. "Fruit Loops! Now with added allergy-preventing fibre!"

Decide what figure supports your paper best, then search all available data for the best match?

I agree with Ravn about immune activation rather than the cause of that activation being the trigger for ME. Some people might be primed to enter the ME state, and it doesn't matter whether it's a microbe or physical injury (even microtears from normal exercise); what matters is that some...

My tinnitus started well before my ME. I didn't notice any drastic change in it when I did develop ME. I think there may be a link between neuroinflammation and tinnitus, and ME seems to involve neuroinflammation, but tinnitus isn't unique to ME. I like to blame ME for all sorts of things...

It certainly does sound like a major boost to 'seeing' what's going on in brains. Even with its limitations, some 'before, during and after PEM' scans might reveal something useful.

Yes, I wasn't under any elevated pressure when I developed ME. I'm sure plenty of people were also living a low-stress lifestyle when something triggered their immune systems which in turn triggered ME. How much support is there in the research community for the reliable identification of...

An immune activating event somehow triggers some neurological changes, and some sort of feedback mechanism keeps the body locked into this abnormal state. I figured that out many years ago, without a medical degree. I don't have any solid evidence of the mechanisms involved ... and neither do...

This might explain why conjugated linoleic acid improves my sleep. Too many complex interactions for me to be sure. I'll add PPAR to my list of terms to search for occasionally, for new insights into ME.

I can only think of one example: a friend had a canker sore in his mouth, so his Chinese mother sent him to a TCM doctor, who prescribed 'watermelon frost (fungus on watermelon leaves)', and that worked really well for him. My guess is that TCM tried all sorts of different treatments for this...

This statement would apply just as well to treatments picked randomly and intended for other diseases. Take a bunch of ME patients, give them toe fungus treatments and spleen transplants or whatever else, and maybe throw in some magic crystals and mystic rituals, and you'd get some patients...

Once someone develops a proper neurological basis for how neurological function affects thoughts and emotions, it would probably be better to start a completely new branch of science. Psychiatrists need not apply, except as freshmen. Way too much baggage. What comes to mind is the eastern...

It fits my thoughts on ME, just with higher detail.

Well, I guess there are some people who actually do deserve to develop ME. Then see how happy they are with nonsense doubletalk.

This viral infection may have been the trigger, but not the cause of her ME. I had viral meningitis ~10 years into my ME: it made my ME symptoms worse for a couple of days. I do agree that ME needs to be recognized more easily by physicians, whether it's post-infection or any other trigger...