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Yes, since we don't know the field of view necessary to find ME's abnormalities, we might need studies at different scales. If a brain-wide scan shows abnormalities, they can probably get funding for a higher-resolution, smaller FOV study. Patients are likely to show abnormalities in different...

I like that they're using more than healthy controls. Since I believe ME is neurological (or neuroimmunological), this is the kind of ME research I like to see.

Comparisons with healthy controls are likely to show the differences between 'sick and inactive' people and 'healthy active' people, rather than be ME-specific. This morning I was trying to get an old chainsaw to work. There are three adjustments for the carburetor, and they all have to be set...

I was thinking more about this one. Are there any ME symptoms that absolutely 100% cannot be due to neurological dysfunction? Even muscle dysfunction could probably result from neurological dysfunction, possibly through many steps, but the brain is the master controller for the body. It may...

No, that's not necessary. Some of us, such as myself, had reliable PEM that gave reliable symptoms but didn't cause lengthy crashes. A 40 km bike ride (hilly terrain) would reliably trigger PEM 24 hrs later, which would last a day or so. Surely I'm not the only one who had such reliable PEM...

Any system that offers benefits is going to have people trying to manipulate it for their advantage. The decision makers need to be aware of the latest methods of manipulation. Personally, I think schools should have mandatory classes in manipulation techniques and how to notice when they're...

The shape is all vague and wobbly, because it's likely a set of downstream symptoms that varies with genetics, epigenetics, and various other factors. Those factors affect our individual responses to various other factors too. My priority for PEM would be to find some people with reliable...

Their graphic is just vague speculation. How does that "start to paint a clearer picture"? Until they can find a clear difference in mitochondrial function in all PWME, it's still just a wild guess as to what the mechanism of ME is. Mitochondrial function is probably involved, but cause or...

Nope, you'd be lacking the "unique mixture of negative oxygen ions in this environment". That's an excellent excuse for why this technique--which is so amazingly effective (wild guess, since i haven't read it) in their study--doesn't work for anyone out of the study. ;) I just spent an hour...

Which also means that changes occur in response to disease. Now they need to figure out which changes are causes, and which are effects.

Oh, which mechanisms are those? They list some symptoms, but not any cellular mechanisms. My guess is that they don't have a good grasp of ME, they're just trolling for newsworthy numbers. Another guess: they were hoping to find something amazingly different, such as 80% of PWME having an SNP...

If Tide said that their new detergent was quantum-resonant-enhanced for greater whiteness, I'm sure they could make up some numbers to prove that it works.

Is the Mediterranean diet high-fibre? I never thought it qualified for that. AFAIK, it's the fibre that feeds/supports the bacteria that produce the SCFAs. Hmmm, isn't SCFA production mostly in the colon, while intestinal permeability problems generally occur further upstream? My...

Alas, I became sensitive to fibre metabolites (I believe it's the propionic acid, but it could be the butyric) a couple of months ago. After decades of above average fibre intake (with no problems from it), even small amounts will make me extremely groggy and sluggish the following day, and it...

I expect on some of those questionnaires, if you answered 99 questions 'no' and one that was vague enough to be considered 'yes', the psychiatrist would say: "Aha! You are definitely depressed. Here's your prescription. Problem solved." I suppose a lot of questionnaires are just...

What would a questionnaire about the usefulness of questionnaires show?

Catastrophizing? Kinesiophobia? Leading the subject much?

Darn, I thought the wound healing application had been verified, and I thought I'd read about it in a credible source. Maybe someone will start rating the journals on their percentage of published papers that actually get verified by one or more other groups.

Well, they're nearly identical in that they involve scientific-sounding concepts that are mysterious to most people, and thus easy to make magical claims for. "Magical" electricity and magnet treatments have been around for hundreds of years ... with no proven success, so reskinned versions...

I have an alternative hypothesis: that it's not the overall effort of the activity, but the microtears that occur when using your muscles in ways that you don't usually do, which in turn activates the immune system. I could ride my bike for hours without triggering PEM, but climbing a ladder...