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Maybe these were people who didn't have ME to begin with, and found a different diagnosis. I also wonder what the results would be from people who would have fit the criteria for the study, but didn't get the 'specialized treatments'. I'm sure some would also have improved. Also, did the...

It sounds reasonable to me. I'm convinced that my glial cells are closely involved in my ME, so this fits. It might not require increased ATP; it could be other mechanisms that affect how the glial cells function, which in turn affects the ATP->damping function. Since many of us suffer from...

My ME trigger wasn't clearly an infection. A tetanus booster may have been the trigger, but the first notice of something being wrong was what felt exactly like the onset of a flu, except that it was gone the next day. A couple of days later, it happened again, more severely, but still...

Another study with limited knowledge of how varied ME really is. Some of us don't suffer from physical fatigue or a significant reduction in our body's efficiency. Some of us have the mental symptoms (mental lethargy/fatigue) without the physical symptoms: the Canadian and International...

There's a lot that isn't covered by the available methods of brain imaging. I'm not sure what the smallest range of chemical signalling is, but I expect it's only a few cell diameters. Available methods just don't scan that scale, and not at a relatively huge distance through a thick skull...

Yes, on PR, several other members stated that they didn't get physical limiting symptoms either. Some of them continued what sounded to me like pretty heavy-duty bodybuilding exercises. There seems to be a subset of ME victims who don't suffer muscle-limiting symptoms. IIRC, at least one...

Nope, haven't found anything like that in journals. It's just my theory based on observations of my PEM in response to exertion. Earlier today ( https://www.s4me.info/threads/is-me-a-metabolic-problem-or-a-signalling-problem.10981/page-7#post-290644 ) I posted a link to a paper on creatine...

Unrelated plant. No cuminaldehyde.

No, I used several no-name packages of ground cumin, and bulk seed from at least two different stores, and they all worked the same. Some exotic brands might not work as well, since cuminaldehyde content does vary with where it's grown, but the cheap stuff available here in Canada seems to work...

Repeated testing, while holding as many other variables as possible constant. With the cumin, I found a list of compounds found in it, and tried other herbs and spices that contained subsets of that list. Cuminaldehyde seemed to be the most likely chemical. I couldn't get any other source of...

Maybe because brain cells are hard--and expensive--to scan in high detail? It's hard to measure how tightly astrocyte feet are clamped around a blood vessel, or how much quinolinic acid is being produced in a small clump of cells, and it probably doesn't take all that much variance to cause...

I wonder if stress is a factor in that. Reading a technical document for self-education doesn't involve emotional stress, so it doesn't trigger PEM for me. Filling out taxes or making decisions involving large amounts of money is stressful, and does trigger PEM. Likewise, I think that talking...

That's true as far as I know. I found that in one or more papers. I think it's normal for activation of the body's immune systems (t-cells, b-cells, maybe others) to activate the brain's immune system (glial cells). The brain is critical, so the rest of the body gives it warning signals just...

I'm not sure how you can know that, since it would be hard to tell when the virus starts replicating enough to trigger the immune system. Also, if it was triggered by the virus--or rather the immune system's response to the virus--that would be independent of exertion. I could certainly see...

No. I did have a brief period (few months?) where I had what might have been OI (abrupt exertion would drop blood pressure in my head), but that passed. Another example of what did and didn't trigger PEM: shovelling soil normally (stomp shovel in, toss soil into wheelbarrow) didn't cause PEM...

I voted 'yes, after exertion', but I'm not entirely convinced that it's due to ME. My sleep seemed normal for the first decade or so of my ME, and then I had more trouble sleeping, so age might be at least partly responsible. If someone gives me an effective treatment for ME, I'll see if my...

I didn't answer the question about refreshing or not refreshing because I think my sleep refreshes what it normally should, but ME gives a continuous feeling that is similar to being unrefreshed. Does anyone else feel that 'unrefreshing sleep' as a symptom for ME should actually be 'I feel...

I voted for 'no effect' since eating in general doesn't affect my symptoms. That's ignoring certain (all too many) foods that I have a bad reaction to. I've yet to find a food that gives me a beneficial reaction. :grumpy:

A couple of years ago I discovered that cumin (cuminum cyminum) was very effective at blocking my physically-induced PEM (didn't affect cerebrally-induced PEM). A level tsp of ground cumin would completely block PEM for 3 days. If I forgot my dose, and PEM started, taking cumin then would...

I think it's possible that some PWME could sustain permanent damage, but I think that's not typical. I can't even estimate how many PEM episodes I've had, and none have seemed to have caused any permanent damage. Furthermore, even after many PEM episodes, I still got temporary remissions that...