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    Sleep meds poll

    Melatonin can help me fall asleep, although it's not all that reliable. However, if I take it after 2AM, it leaves me feeling severely groggy the next day, worse than not sleeping at all. 5-HTP also worked, but I can't recall whether it had the same grogginess effect. Tryptophan might have...
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    Pain meds poll

    I did suffer from neuropathic pain, but I treated that quite well with LDN, and after a year or so, I no longer had that pain. I still may develop it when my other ME symptoms are severe, but it passes on its own.
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    Sleep meds poll

    With any of the sleep meds, I'd worry about dependency.
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    A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics, 2020, Giorgini et al

    I'm convinced that problems in the cerebral kynurenine system are a significant part of my ME, so this paper provides another possible explanation for how.
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    An Inflammation-Centric View of Neurological Disease: Beyond the Neuron (2018) Skaper et al

    Yes, but my post was just making a humorous connection to Mithriel's avatar. Poor bear. Surely finding your teddy all poked up would cause ME. ;)
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    Does existing science sufficiently demonstrate that exertion is the correct focus concept?

    I'm definitely an outlier. Others have reported ME with no loss of physical performance, but I also was very effectively treated by cumin and T2, which haven't worked for anyone else. I think that outliers have the potential to reveal otherwise hidden aspects of ME, but as you say, we could...
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    An Inflammation-Centric View of Neurological Disease: Beyond the Neuron (2018) Skaper et al

    Adverse childhood events? As in "You developed ME because you found your teddy bear stuck full of needles when you were 3 yrs old?" ;)
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    Repeatability and reproducibility of in-vivo brain temperature measurements - 2020 Sharma,Younger et al

    That's an important part of science: establishing the reliability of new measurement techniques. Without it, a study of ME brains with this technique is just colourful pictures.
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    Does existing science sufficiently demonstrate that exertion is the correct focus concept?

    It makes perfect sense to me. You used muscles beyond their normal limits, which triggered your immune system to clean up the damaged cells, and the resultant cytokines caused your symptoms, directly or indirectly.
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    Does existing science sufficiently demonstrate that exertion is the correct focus concept?

    I suffered malaise after exertion, so that's within the definition. It doesn't say post exertional endurance loss. That didn't seem to be part of my PEM either. I felt much worse when the PEM kicked in, but I didn't notice any reduction in endurance. I expect that my legs would have managed...
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    Does existing science sufficiently demonstrate that exertion is the correct focus concept?

    Actually, I'm a poor choice for explaining the differences, because my PEM was non-standard in some ways and I never had crashes. I've simply read lots of other people report a wide variety of responses that get labelled "PEM", which I didn't experience myself. For me, PEM was simply a...
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    Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for [ME/CFS], 2020, Mitchell et al

    Maybe if they subdivided the groups based on astrological signs, or first letters of their names (or their pet's names), or some other such random divisions, they'd eventually find an even stronger statistical correlation. :rolleyes:
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    Effectiveness a herbal medicine (Sipjeondaebo-tang) on adults with chronic fatigue syndrome, 2020, Shin et al

    "Our research goal is to make some random numbers appear to say something we want them to say." :rolleyes:
  14. C

    New Name For "Brain Fog"?

    If I had to vote on a term listed so far, I'd go for 'cognitive dysfunction'. I imagine it as something subtly altering the functioning of individual neurons.
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    Brain astrocytes & microglia express functional MR1 molecules that present microbial antigens to ... (MAIT) cells, 2020, Priya et al

    Yet another understudied component that could be involved in ME.
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    Does anyone have a list of common ME symptoms please?

    I recommend keeping a food/activity/symptoms journal, as detailed as you feel up to. As you've found, human memory, even without ME, is too fallible for accurately remembering such data. A list of symptoms will help start that, but I don't have a convenient one. Search for the criteria for...
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    Kynurenine pathway is altered in patients with SLE and associated with severe fatigue, 2018, Akesson et al.

    The B12 = niacin error jumped out at me too. :) What was missing from the abstract is that they only measured serum and urine levels of metabolites. Since central fatigue is neurological, and many kynurenines don't cross the BBB easily, I consider their findings to be fairly useless. If...
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    Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit, 2020, Yamashita

    Even before I knew about ME, I was aware of how TRP increased my symptoms (unless I also took BCAAs), and how exertion and viral infections (increases IDO) similarly increased my symptoms, so this paper fits my observations and beliefs about ME. I'd rate this as the most important paper...
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    Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress..., 2020, Wang et al

    Just think about all the parts about B12 metabolism that researchers haven't even discovered yet. :)
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    Unravelling intracellular immune dysfunctions in CFS: interactions between protein kinase R, RNase L cleavage, elastase, 2008, Meeus et al

    Another older study that found something possibly useful...but was never followed up on?
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