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I agree with arewenearlythereyet: this 'Nobel-candidate' hypothesis seems to boil down to: "something in the body is malfunctioning!". Unless there's an effective "repair homeostasis" treatment, it's not a useful hypothesis.

Nice to see that they included covid-like controls.

Negative results are useful too. :thumbup:

Someone should do some studies of microbiomes of patients with broken bones, gunshot wounds, or other such trauma. Will they find changes in the microbiome? I expect they will. Eventually, they can come up with some methods for determining when microbiome changes are actually caused by a...

I think that (testing whether PEM can be triggered by electrical muscle stimulation) would be worthwhile. There are other possibilities, such as the cognitive effort to get those muscles moving being responsible for triggering PEM. I'm pretty convinced that muscle damage, and the consequent...

I think that just indicates that the device isn't measuring what you think it's measuring. Extreme physical exertion probably raised heart rate and resistance to blood flow. I suppose it's possible to have a fast heart rate and low resistance to flow, which would be the same 'power level' as a...

Not every PWME gets PEM from physical exertion either, or even gets it to the same degree from the same exertion. I could hike or bike for hours without triggering PEM, yet climbing a ladder once would trigger it. I expect that a lot (most?) of us have both triggers to some degree (although I...

This study came up on PR, and my comment was that researchers should look into using cognitive triggers for PEM. Maybe socializing for 10 minutes will produce the same level of PEM, but with less harm to the patient. It would also avoid extraneous factors resulting from the physical exertion...

It wasn't easy. I knew that something in high-protein foods was making my symptoms worse. Peanut and soy butter had the same effect, so it wasn't meat-only. Then I remembered that I had some gelatin in my cupboard. That was the worst trigger yet, and it's essentially amino acids, and three...

I was suspicious of Complex V long before I knew about ME. I thought I had some problem with kynurenine production, which involved superoxide and Complex V. There were some other factors, now forgotten, that kept me suspicious. Now I've become sensitive to proline, which reduces activity of...

That doesn't help with understanding the impact of cognitive exertion. :thumbsdown: Experiments with cognitive exertion could lead to less-harmful methods of triggering PEM for research projects. That's assuming that cognitive-induced PEM actually is less harmful, which we don't know for...

They could also induce PEM via cerebral exertion. Does anyone know whether socializing or other cerebral exertions are as likely to cause crashes as 'maximal exercise tests' are? I was going to suggest this to the researchers, but I couldn't find a way to contact them.

I think of it as being in prison for something I didn't do, with no idea when, if ever, I'll be released. I certainly don't have the freedom to do what I would like to do.

There's funding for ageing cats, but not for humans with ME?

I think "quasiexperimental" means "We'll start with the results we want and make up the experiment to provide them." :rolleyes:

Researchers should put out a call for anyone who is able to trigger temporary remissions reliably, even if it's only for a few times. Get the patient in a lab, do extensive testing, trigger the remission, then redo the tests and see what's changed (and redo again when switched back out of...

I feel that an even stronger argument for ME being reversible is temporary remission. I had several, more frequently at the start, with the last one maybe in year 5 or so, with none in the last 14 or so years, alas. :( These were an abrupt switch from full ME to apparently fully healthy...

I have one (molar), gotten several years into my ME. I didn't have any problems healing quickly, or any other problems with it. My ME doesn't keep me inactive or horizontal though.

I didn't notice and difference in PEM between +30C and -40C. Swimming in my creek in winter would require considerably more effort. That water is hard! :D

I didn't notice any difference during PEM. For me it was just 'fatty meal without carnitine = worse symptoms. With carnitine = no extra symptom severity'. I didn't need 3000 mg either; I think I took half a level tsp or so.