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Doesn't everyone suffer from post-exertion fatigue? I call it: "Getting tired". :) For ME, I prefer to use the term 'fatigue-like' instead of fatigue, which is a poorly defined term in any case. Are there any definite clinical measures of normal fatigue? For a normal, healthy person, does...

My ME also started with ‘I have felt that the flu is coming'. The muscle aches/body tenderness and overall malaise seemed identical to previous flu infections. However, the next day I felt fine again. Then a week later, the same feeling occurred, and this time I felt feverish and really...

The trick is in how you define 'works'. For psychology/psychiatry, you just choose some unquantifiable targets and choose your questions to give your desired results.

One problem is that if you want to find a cause of something and there's no way to prove or disprove the cause, it's fairly easy to find something to blame. I had a tetanus booster some months before I developed ME. Was that the cause? There's no way to test that. Did I sneeze at least once...

When I saw the thread title, I checked to see whether they meant that the more pain relief web sites available, the more people would seek medical help for pain. The actual research finding was no less silly. :rolleyes:

I wonder whether this might provide some useful markers for ME.

I have a couple of type I allergies (Timothy grass pollen and what is probably fungal spores) but neither affects my ME symptoms. I think that for some people, type I allergic reactions might indirectly worsen ME symptoms, possibly through extra cytokines or depletion of resources or some such...

Alberta was quick to declare the emergency over and drop all restrictions. Now they're admitting that they were too optimistic, and the big surge in cases is filling the ICUs. I haven't noticeably changed my lifestyle due to Covid. I went to town only when I needed to before Covid, and still...

I really don't consider 'aesthenic disorders' as being a superior term than 'central fatigue'. Central fatigue isn't well-defined, but at least it has some definition. How about we stop trying to rename things that we can't clearly define? If we manage to find a clinical cause of this...

While the trial doesn't seem to show strong evidence to support the claims for the drug, I haven't seen any dismissal of the hypothesis for the root cause of ME. The drug might fail to work as theorized for any number of reasons. I hope that someone follows up on the hypothesis itself. Maybe...

Niacin gave me suicidal thoughts, and hot flushes when I took an actual tablet of it. Maybe try a niacin tablet or some food rich in niacin and see whether that causes any of the symptoms. As others have said, changes to gut permeability or microbiome could explain the responses to various...

Since yawns are contagious, does that mean that fatigue is? :yawn: I'm surprised that they didn't use muscle movements or posture as features. I'd expect frequency and speed of movements to decrease with fatigue. My question is: how did they determine the accuracy of their fatigue...

Some people wonder why researchers haven't figured out the root cause of ME. Well, the body is immensely complex, with all sorts of subtle but important interactions. We read about these new discoveries, but how much is yet to be discovered?

The 'come up with therapies' part may be a wee bit optimistic, but we won't figure ME out without data, so the more projects collecting potentially useful data, the better. I believe that ME is primarily neurological (with downstream effects on the body), so I support studies of the brain.

"Haze figuring" sounds like if fits ME. "My thoughts get lost in the haze." :unsure:

Paid work for the researchers? It seems unlikely that it will benefit patients more than just telling them to pay attention to changes in symptoms and keep a food/activity/symptoms journal. We all differ too much in our symptoms and responses to factors for any general findings.

These specialized microglial cells might respond to the same triggers that regular ones do, so the neuroinflammation found in ME patients might involve these cells too, messing up blood flow.

I got PEM from driving. The worse the driving conditions, the worse the PEM. Driving in the dark, in heavy snowfall, on icy roads, triggered severe PEM. The same drive during a sunny dry-road day usually didn't. I think it was the cerebral processing of inputs and the stress of the increased...

I tried CoQ10, with and without supplements, and with a reasonably healthy diet ... and didn't notice any effects. Even well-conducted trial results can be interpreted in ways that don't match reality very well.

"You appear to be my healthiest patient."