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Aside from the psycho-nonsense issue, different brain activities have different effects on overall feeling. Playing a strategy game past 2:30 PM gives me insomnia that night, but playing a first-person shooter game (mindless shooting of zombies) doesn't. Maybe some neurons deplete something or...

The amazing thing: there's probably someone out there who is actually proud of creating this nonsense. :rolleyes: Oh, and if it doesn't result in a major accolade for transforming patient care, it will of course be the fault of the nurses for not implementing it properly, or the patients for...

It could be, but it could also be just a malfunction that evolution hasn't weeded out yet. If your computer stops working because a single transistor ot trace failed, it isn't because it's trying to protect itself from further damage.

Died from being left behind because "You look fine, you're just being lazy." :(

Maybe they saw that by a few minor changes in their procedures, they could qualify for ME research funding. That's likely to happen with other research projects: put out the sweet smell of money, and pesky bugs come around to feed... :mad:

I wonder whether long covid has the same 'treatments often work great the first few times, then stop working and never work again' syndrome.

I posted a link to a new finding on Phoenix Rising regarding another possible mechanism for ME affecting heart rate. They found glial cells in the heart, which are part of heart rate control. I believe that ME affects glial cells, so that could affect heart rate. Eating could alter immune...

I'm convinced that ME is neurological, so I don't expect serum studies to reveal much other than some downstream effects.

This offers another possibility for chronic inflammation: those neurons might be maintaining the active state after the trigger has been removed. If you add in ME altering neural function, it could be locking us into a feedback loop, with the inflammation altering the neurons in a way that...

Is there any way we can convince psychologists to come up with ways to fix their own problems? They shouldn't give (bad) advice to other people until they fix their limited perspectives and poor experimentation procedures. :grumpy:

I'm unconvinced that this hypothesis fits with the rapid switching between full ME symptoms and full temporary remission. This switch of state takes place over a scale of minutes rather than hours. I triggered remissions via three different chemicals: prednisone, cumin, and T2. I don't see...

I think if it was an effective treatment for ME, someone would have noticed it after taking butyrate supplements. I've had different antibiotics and drastic diet changes, which should have affected my butyrate production, but I didn't notice any significant differences in my ME.

I came across this news item just after reading this thread, and it seems to fit it: https://newatlas.com/health-wellbeing/microbiome-gut-bacteria-inflammation-colitis-pgp/ "But more recently P-gp has been found to also play a key anti-inflammatory role in the gut, producing molecules known as...

I'm sure my microbiome would be abnormal. There are so many foods and food families I need to avoid that my food diversity is greatly reduced. For many PWME, reduced activity levels might also affect the microbiome. Studies such as this really should use controls with similarly reduced...

If they're studying the neurological effects of QA, I don't think they should be using serum samples. Most QA in the brain is produced locally. The correlation they're probably measuring is from the disease affecting cognition via local QA production also affecting QA production elsewhere in...

Seems like a good candidate for further investigation. My brief skim made it sound like magnesium supplementation should have an effect, but I haven't noticed any, but maybe it's not that simple.

If the goal of a study is a desired outcome, for whatever benefits to the authors, it's all a matter of choosing experiments or carefully selected data that supports the outcome. A well designed study of something silly, such as whether slugs move more erratically during a full moon, is...

I can't recall anyone claiming reduction in ME symptoms from taking lecithin (leads to myo-inositol ) oranges or cantaloupes. Oranges (a source of myo-inositol) were the initial immediate trigger of what became my ME, although that might not be related to myo-inositol (but can't rule that out).

Good. It seems pretty obvious that there's a need for that.

We can't even clinically verify ME in humans, and going by questioning humans (who can communicate in words) is fraught with difficulties, so any claims for rats with ME seems kind of meaningless.