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I tend to eat slowly, and in hospital I have previously lost weight due to food being taken away before I've finished it, e.g. when I have had to interrupt a meal to go to the loo. I ended up putting my unfinished food in a locker when leaving it, and finishing it when I came back. On another...

I didn't know what UES stood for so looked it up: Upper esophageal sphincter, the superior portion of the esophagus (presumably)

Having never heard of alexithymia I looked it up: https://en.wikipedia.org/wiki/Alexithymia "Alexithymia is a neuropsychological phenomenon expressing important difficulties in identifying and describing the experienced emotions by oneself or others.[1][2][3] It also involves emotional issues...

Have they got degrees in idiocy? "The heterogeneity found in biopsychosocial factors" means that they are barking up the wrong tree!

I took lots of LSD and magic mushrooms in the 70s and 80s. I don't have chronic pain, but sometimes got back pain on LSD. It doesn't sound worth bothering with. I seem to recall that his stuff is generally not very good.

There's a very long article about him on Wikipedia: https://en.wikipedia.org/wiki/Hans_Asperger I haven't been able to read it all, but there seem to be lots of different opinions and interpretations.

I often find that bowel movements are incomplete, urgent or unpredictable, hence disruptive.

Have you tried a dose of sodium bicarbonate in water? I find that that makes me burp, as well as making me feel better.

Oh dear - the difference in language between UK English and US English again: "We’re talking about bonked, the feeling of nothing left, not able to move your limbs." Bonked means something somewhat different in the UK!

I have a Master's degree in medical science, although my understanding has deteriorated considerably in the last few years. But my first thought is that excluding non-responders wouldn't be very scientific.

Isn't it only biomedical research which should be carried out into ME by the NIHR and MRC?

No expertise, just want to wish you all the best with whatever you decide.

Yes - Alzheimer's is still very uncertain. I studied it for my Master's degree, and even after death the pathology isn't clear - there are plaques and tangles but these are also found in people without dementia.

I think that the Vinks have been very active in the field for some time.

My mother died from lung cancer due to smoking, in 1960. I'm pretty sure that it was known that tobacco was addictive by then, because my father smoked as well but stopped when my mother was diagnosed.

Interesting. I take 2.5 mg Nebivolol daily myself, having researched anti-hypertensives some years back when I was still capable of researching, It's the only anti-hypertensive I've tried that doesn't have side-effects for me. It doesn't always/often reduce the systolic pressure all that...

I haven't yet worked out what pain drawing is! I did a quick internet search but struggling with a misbehaving mouse...

The inclusion of Jon Stone amongst the authors doesn't fill me with confidence... https://www.neurosymptoms.org/en/

I used to drink a lot, including after getting ME, but a few years ago (after having ME for many years) I developed an inability to drink much more than a small glass of wine a day.

What are 'overnights'?