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  1. forestglip

    Relationship between major depressive disorder and [ME/CFS]: a two-sample mendelian randomization study analysis, 2025, Zhu et al

    Looking at Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19, Li et al. In "Supplementary Table 7. The Association of IVs With Exposure and Severe COVID-19" it lists a lot of SNPs. Interestingly, the first five listed...
  2. forestglip

    Relationship between major depressive disorder and [ME/CFS]: a two-sample mendelian randomization study analysis, 2025, Zhu et al

    Also checked and none of the SNPs match with Supplementary table 1. I also checked Supplementary Table 2 from Howard et al just in case since it lists SNPs, but none of those match Zhu et al's 57 SNPs either. I checked the first few SNPs shown in figure 2 A and D from Zhu just in case those were...
  3. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    In the interests of trying to improve the forum, sure, I'm talking about Amy Proal. https://www.s4me.info/threads/hypothesis-piece-by-amy-proal-a-microbiologist-with-me-cfs.134/ I don't know much about the Marshall Protocol. It might be completely wrong. But I think there are a million ways to...
  4. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    I don't know if it's worth naming this person, but at least one researcher clearly reacted badly because of being the lone person defending themself against a whole group of people basically calling them stupid, some implied and in some cases pretty much explicitly. I don't blame them for...
  5. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    That seems like it might be a good idea actually. I imagine at least some will want to take a look out of curiosity, and hopefully a few will want to clear up any misconceptions or clarify anything important that we're missing.
  6. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    I glossed over this before. What do you mean "start Covid-19"?
  7. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    I've thought the same. I have pretty bad social anxiety disorder, another condition that very often has no effective treatment, and there are a couple big forums for that, but no one is posting about the ongoing research, just sharing experiences of symptoms and of trying existing treatments. I...
  8. forestglip

    News from the Institute of Neuroimmune Medicine (INIM), NOVA, Nancy Klimas

    Wow that conquercfs thing is expensive. The standard course is £1,750 and the ultimate course is £1,999. (I think you can also pay a couple hundred a month instead. Edit: and there is a cheaper "emergency reset" course for £39/month.) The ultimate course includes three one-on-one calls with the...
  9. forestglip

    PolyBio Fall 2024 Symposium

    2:50:17 Petter Brodin–Sex Hormone Regulation of the Immune System Main takeaways: Peter Brodin's lab is interested in genetics of long COVID, particularly genes involved in antiviral immunity. They hope to report results of a whole genome sequencing study of 110 people with severe long COVID...
  10. forestglip

    Preprint Investigating the Severity and Timeline of PASC Symptoms: Focus on Physiological and Cognitive Effects,

    Investigating the Severity and Timeline of PASC Symptoms: Focus on Physiological and Cognitive Effects Rohan Melwani, Keerthana Noru, Sanya Kondapalli, Ameya Ravi, Saanvi Shah, Shreeya Setty, Shashank Sastry, Sahar Jahanikia [Preprint] Abstract The SARS-CoV-2 virus, responsible for the...
  11. forestglip

    Preprint Effect of Immunoadsorption on clinical presentation and immune alterations in COVID-19-associated ME/CFS, 2024, Anft

    Well, spike protein too. Do you know why that would happen? Edit: From discussion about spike protein findings: So likely just: "However, since high titers of SARS-CoV-2 spike protein specific antibodies were detected in all patients, it is likely that these antibodies bound to soluble spike...
  12. forestglip

    What high-quality resources should S4ME produce for PwME, clinicians, researchers etc.?

    Also maybe some information about using supplements. I often see people on social media posting that they take like 30 supplements. Apart from reiterating that most supplements have no evidence behind them, maybe there could be general info about placebo effect, confounders, and that...
  13. forestglip

    What high-quality resources should S4ME produce for PwME, clinicians, researchers etc.?

    I've seen several places suggest that PEM can be immediate in some people. CDC might have wanted to be inclusive just in case, so that someone whose PEM starts immediately isn't discouraged seeing this saying PEM must be delayed. Edit: From another thread:
  14. forestglip

    Preprint Effect of Immunoadsorption on clinical presentation and immune alterations in COVID-19-associated ME/CFS, 2024, Anft

    Even without a control group, we do see that these may be real effects of the intervention, since they rebounded afterwards: I don't know if any of that is actually relevant, though. Why would IgG removal decrease spike protein in the blood, and only temporarily? And though self-reported...
  15. forestglip

    Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation, 2023, Salvucci et al

    Not placebo controlled. They looked at records of patients who had and had not taken antihistamines.
  16. forestglip

    Scent of COVID-19: [WGS] Analysis Reveals the Role of ACE2, IFI44, and NDUFAF4 in Long-Lasting Olfactory Dysfunction, 2025, Spedicati et al

    Scent of COVID-19: Whole-Genome Sequencing Analysis Reveals the Role of ACE2, IFI44, and NDUFAF4 in Long-Lasting Olfactory Dysfunction Beatrice Spedicati, Alessandro Pecori, Maria Pina Concas, Aurora Santin, Romina Ruberto, Giuseppe Giovanni Nardone, Andrea D’Alessandro, Giancarlo Tirelli...
  17. forestglip

    Hypothesis Calcitonin gene-related peptide-induced central sensitization: A hypothesis for long COVID symptoms, 2025, Ella J. Lee et al

    Calcitonin gene-related peptide-induced central sensitization: A hypothesis for long COVID symptoms Ella J. Lee, Cynthia Tsang, Martha Lucía Gutiérrez Pérez, Mehdi Abouzari, Hamid R. Djalilian Abstract Central sensitization (CS) denotes aberrant processing of sensory stimuli within the central...
  18. forestglip

    Donating and fundraising by people with ME/CFS - discussion thread

    My guess is lots of fundraising depends on the participation of a significant number of people with the condition, or who have had it or think they might get it. People directly impacted will naturally have much more motivation to find cures than the general public. I think it's possible the...
  19. forestglip

    Burden of Infections in Early Life and Risk of Infections and Systemic Antibiotics Use in Childhood, Brustad et al, 2025

    Maybe this is standard researcher speak for "associated with", but to the general public I think this could easily be misconstrued as causal. I didn't thoroughly read the paper, but I didn't see any evidence that infections in early life cause problems later in life. Seems likely they're just...
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