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Also appears to match with the paper. I don't know if this heatmap is ordered by most correlated at the top, but the top four are the same as the top four in my list, although in a slightly different order. And it seems to also show that most of the metabolites they chose to illustrate are...

Yes, I think these are correct. I just averaged the metabolites for each group directly in the raw data file and the mean levels in ME/CFS are lower than HC in the top five negative correlations and higher in the top five positive correlations. (ME/CFS is 1, HC is 0.) Highest negative...

Maybe the Deep Phenotyping study data if you have/can make a mapmecfs account. The names of all the datasets are viewable without an account: https://www.mapmecfs.org/dataset/?organization=nih-intramural

I thought that was weird too, but the first 102 molecules are all lower in ME/CFS. Only 27/445 molecules are higher. Which seems fishy so I may have done something wrong, but I'll manually check some of these, probably tomorrow.

I downloaded the raw data from mapmecfs to dig around in. First little thing I did was get the correlation of every molecule from the metabolomics dataset with the group. Used point biserial correlation and Benjamini–Hochberg correction. Here are the top 40 out of 445 total molecules: And...

I don't see them suggest that maybe the reason the patients with higher side effect expectations did worse was because they know their bodies. All the interventions require some degree of physical and/or mental exertion. If they have experienced PEM in the past, surely they'll be more likely to...

Interesting. Here's a bit more from the first paper on PET: That's interesting that PET was much less sensitive: I'm not sure why the poster says 45 but the abstract says 48, though:

Same author, looks like an abstract for a presentation at Demystifying Long Covid 2023 conference: Single-photon emission computed tomography facilitates the diagnosis of vascular encephalitis in cases of severe Long Covid and correlates with transcriptomic studies, 2023, Jamoulle et al So...

Germain et al 2020 reported higher sphingolipids than controls. It seems phosphatidylcholine wasn't significant.

Not a lot of correlation using Bell scale either. Lower scores indicate more severe disability. BAS vs change in VO2 at VAT: BAS vs change in workload at VAT: Correlations (only MECFS): Correlations (full cohort):

The German late night talk show ZDF Magazin Royal hosted by Jan Böhmermann did a full episode on long COVID and ME/CFS. Some quotes from an AI translation: So in the Jon vs John race to cover ME on their show, amazingly the winner is Jan.

Later in the paper they say:

I checked a couple other potential fitness metrics (VO2 peak normalized to weight on day 1 and VO2 at VAT on day 1) against the difference metrics, but nothing stood out to me there either. I don't see anything here that makes me think deconditioning is associated with a decrease on second day...

I made some charts to see if there is any obvious indicator that decreases in CPET metrics correlate to deconditioning/fitness. I charted using VO2peak as the deconditioning metric, as well as percentage of 24 hours lying or sitting, number of hours in bed during 24 hr day, and BMI. Greater...

I just checked all means for those two metrics (VO2 and VO2/kg). The only one that didn't match up with my calculation was full cohort of controls on day 1. I got 12.18 instead of 12.7. This shouldn't affect the effect sizes you were talking about, though @ME/CFS Skeptic .

Are the reported mean metric values correct? Looking at Table 3 in the study at the four values that represent the full cohort of controls for those two metrics you mentioned on both days: 12.7, 11.8 for standardized to weight and 960.0, 934.5 for without weight. The percentage decrease for the...

I wanted to visualize what the differences in the matched pairs were individually, to see how many people in the ME group had a larger difference in the metric than their matched control. If pretty much all pwME had a larger drop in VO2 or another metric than their matched counterpart, that'd be...

The raw data is now on mapmecfs.org.

"JAK stay inhibitors, an existing drug, is our current best guess." He has an impressive resume as a venture capitalist, but does this Vinod Khosla have some connection to ME/CFS? Edit: From Health Rising: Another from HR, about itaconate shunt:

Ah ok, I didn't know those were separate things.