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They've got a few papers on this. I might see if one of the other ones shows where it started later. Would be interesting to check. I forgot I was also planning to see if there are any safety studies on this vaccine that might show something like increased fatigue after a year. I'm not sure...

Sounded fun to try to test. I digitized the image of the plot with WebPlotDigitizer. They're not perfectly on center for each dot, but I'm pretty sure I got every dot's approximate location. The paper says there are 98 dots, and I was sure about 97 of them, and pretty sure about the last. Points...

They didn't actually test real peptides in the lab. They used the NetMHCpan neural network program. You give it the DNA code of the HLA and the amino acid letters of the peptide, and it predicts how well they would bind. Well we have stats to actually put numbers on the relationship. It's...

This one seems to support it, though I haven't thoroughly read it: Antibody Response to SARS-CoV-2 is Associated with Long-term Clinical Outcome in Patients with COVID-19: a Longitudinal Study, 2021, García-Abellán et al ---- Edit: Another one. Not sure what to make of nucleocapsid antibody...

Good point. Do you know that this has been tested? They don't mention observed antibody levels in the long COVID paper. Maybe it hinges on how fast antibodies start getting produced - maybe everyone gets antibodies by day 10, but if they didn't have them by day 5, the virus had a chance to...

They just recently published another paper which is an opinion suggesting that poor HLA binding to SARS-CoV-2 allows it to persist and cause long COVID (1). Maybe also something similar happening with the COVID vaccine not binding well to HLA, since people report that the vaccine seems to cause...

This is pretty interesting. They got the protein sequence of the anthrax vaccine, as well as the HLA genetic code of all the participants. They used a program called NetMHCpan where you input both and it predicts how well the peptide would bind to the MHC (MHC is the protein complex that HLA...

Can someone explain how you can determine that symptoms persist for days because of a tilt test and not just being upright that day for the visit (or anything else about that day that was different)? Isn't it basically shifting a person from horizontal to vertical? So not much different from...

Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules Lisa M James, Apostolos P Georgopoulos Background Anthrax is a serious disease caused by Bacillus anthracis (B. anthracis) with a very...

I think this is unlikely to be a real result because of how extreme the results are, but looking for related literature just in case: Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases, 2019, McGregor, Armstrong et al...

Looks to be comparing to a reference range. Marshfield Labs says 30-100 micromol/L, so theirs seems right. The highest in this study was 17.16 micromol/L. The lowest was 3.58. Edit: Oops, removed Mayo Clinic Labs range. Pyruvic acid is not the same thing as pyruvate.

50:54 – Peter Rowe - Dysautonomia in ME/CFS Main takeaways: Peter Rowe discusses dysautonomia in ME/CFS. There is mounting evidence that orthostatic intolerance (OI) plays a role in ME/CFS. Tilt testing in ME/CFS has shown measurable changes in immediate cognitive function, immediate...

19:56 – Gudrun Lange - Cognition Main takeaways: Gudrun Lange, a neuropsychologist, explains that it is important to test cognitive function in ME/CFS studies, as this is one of the few symptoms which is objectively testable. Unfortunately, objective cognitive tests are not commonly included...

YouTube playlist with all of the webinar videos. Nervous System 10:27 – Trisha Fisher - Lived Experience 19:56 – Gudrun Lange - Cognition 50:54 – Peter C. Rowe - Dysautonomia in ME/CFS 1:14:58 – Jonas Bergquist - The Neuroinflammatory Role in ME/CFS 1:57:30 – Jarred Younger - Neuroimaging...

This seems to be getting a significant amount of traction in the media. I get Google Alerts for news that mentions "ME/CFS" and there have been a surprisingly high number of results for this the past few days. 23 articles in 5 days. And this morning I heard it used as a question in a trivia...

They pre-registered these outcomes: CRP* IL-6* Intestinal fatty acid binding protein (Ifab)* sTNF-RII* Vitamin D3 level Vitamin K2 level* Adverse events They don't seem to report results for the starred markers, but they do report several markers they didn't pre-register. I also don't see...

No placebo for controls:

Vitamins K2 and D3 Improve Long COVID, Fungal Translocation, and Inflammation: Randomized Controlled Trial Ornina Atieh, Joviane Daher, Jared C Durieux, Marc Abboud, Danielle Labbato, Jhony Baissary, Ziad Koberssy, Kate Ailstock, Morgan Cummings, Nicholas T Funderburg, Grace A McComsey...

And the Research Roadmap webinar from a year ago had about 30 hours of presentations from dozens(?) of researchers. There must have been some more fleshed out research from some of these groups since then that could have been included. It felt really out of place to include, in what otherwise...

Just noting that there was a fairly large 2022 study that tried to confirm this team's TCA (or TRA, T cell receptor alpha) gene finding, and they found no association. "large Norwegian ME/CFS cohort (409 cases and 810 controls) and data from the UK biobank (2105 cases and 4786 controls)" No...