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Another of their studies that looked at CBF reduction. Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography, 2020, van Campen et al The current thread's study only...

Same on Android, but if you click the three dots in the top right corner of the pictures you can download them.

I emailed Dr. van Campen about this since I wanted to confirm if it was placed in the methods section by accident. She said it was on purpose, and I realized "related" can mean a technique, as well as a descriptor. So they meant: All this about CBF reduction is looking quite interesting. I...

Interesting chart on there:

Good point. I looked at another of this group's studies: Worsening Symptoms Is Associated with Larger Cerebral Blood Flow Abnormalities during Tilt-Testing in ME/CFS, 2023, van Campen I'm guessing both these studies are looking at the same general set of historical patient records, with maybe...

That part was studied separately from the clinic health records, and it seems like they all fit ICC. They're from two previous van Campen studies on ME/CFS. Van Campen, C.L.M.C.; Rowe, P.C.; Visser, F.C. The myalgic encephalomyelitis/chronic fatigue syndrome patients with joint hypermobility...

If you're referring to the two clusters I was talking about, it's not the healthy controls I'm looking at. It's that it seems odd that a quite large ME/CFS group (n=534) split cleanly with a large gap into two subtypes. One subtype almost indistinguishable from the healthy controls, and the...

They looked at historical records from their clinic for patients who had taken two tilt tests. They divided the records into two groups, those who had no change in symptoms at the second visit (n=39) and those who had worsened symptoms at the second visit (n=71). They looked at how much their...

If there were two distinct clusters, which would be a bit surprising in itself, then the tail end of the blob near the bottom left is what I'd expect on the top right end of the blob. Where it slowly becomes less dense as it fades out. Instead the top right almost looks chopped off. I guess...

Is there a definition already written anywhere that you think would be a good option for this?

Isn't that just a questionnaire with one question?

I'll start it off with a question suggestion: Does mental or physical activity cause fatigue or other symptoms (maybe reference some examples) to be exacerbated far worse than would be expected in a healthy individual, and does this exacerbation normally last at least three days? I still am...

I used WebPlotDigitizer to pull out the coordinates of all the points I could make out for just ME/CFS. The tiny red dots show the ones I got coordinates for. Pretty much all the green ones I could see and all the ones around the edge of the red blob. Here's the plot of just ME/CFS that I made...

What's going on with that chart? They decided to use the range of HCs as a reference, with 15% cerebral blood flow reduction as the cutoff to compare ME/CFS similar to HC (green) and those with larger %CBF reductions (red). Why is it such a perfect split between the patient groups if they...

Microbial involvement in myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology Alejandro Borrego-Ruiz, Juan J. Borrego Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and disabling disease related to persistent fatigue, exercise intolerance...

No idea. Hard to think of what could cause the same thing in so many conditions. My mind usually goes to confounders like less physical activity in many diseases, but I don't typically think of people with ADHD as being less active. (Edit: maybe poor diet both causing low hypoxanthine and being...

PolyBio posted on Bluesky: https://bsky.app/profile/polybiorf.bsky.social/post/3ldr6bynszs2l 1/ BREAKING A new study published in Nature Communications has unveiled a crucial connection between chronic #infection with Cytomegalovirus (HCMV), and the development of #Alzheimer’s disease in...

The deep phenotyping study has the stool metabolomics statistics in Supplementary File 21. These are sorted by significance. Tyrosine, phenylacetate, and threonine are the other ones they found were significant. (All increased according to the spreadsheet above.) Edit: Unclear if they did...

So low hypoxanthine in the stool has been seen in many quite different health conditions (acute COVID, TB, ADHD, IBS, ankylosing spondylitis, RA). One more if you include ME/CFS. So maybe it is a marker of poor health in general. The plot of hypoxanthine in the two groups of this study above...

Since low fecal hypoxanthine was flagged above, I did a search. Plots of fecal hypoxanthine from the NIH study: Plots of hypoxanthine vs other metabolites mentioned in other studies below as lower. Propionate, uracil, and butyrate look like they might be positively correlated with...