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Several of the studies did just that (Hodges 2017 and Larson 2019), but I agree more could help. I've tried to keep the following page up-to-date https://me-pedia.org/wiki/Two-day_cardiopulmonary_exercise_test Those with moderate-severe cystic fibrosis are going to have quite different...

The method is interesting, but claims of "cure" are premature, if not dangerous...

They're often considered to be the same thing, but I think this is a mistake. To me, "Anaerobic threshold" is a misnomer since it doesn't specifically reflect what is going on in the muscle fibres. It is also important to note that arterial carbon dioxide pressures remain relatively constant...

Seems more than a little implausible...

Note that some bacteria express their own HSP60, so that may explain the cross-reactivity, rather than autoimmunity itself. HSP60 is an intracellular protein, so isn't normally exposed to the immune system so antibodies directed against human HSP60 would need its own explanation. I haven't read...

The ventilatory threshold is a physiological set point, the fact that it is reached earlier (in terms of power output) on the second day is objective proof of increased fatigue. Control subjects (sedentary controls and MS patients) are able to replicate their performance at the ventilatory...

I don't understand the logic of requiring severe patients to do this, but... Given this is another replication, how long can medical doctors and other scientists deny that this is the most consistent finding to date? It is frustrating that they're not stating the actual max heart rates of...

It was the puppy-eyes that got you, wasn't it!?!

That sounds painful! (sorry if this in inappropriate, but it is funny!) Seriously though, Fink is trying to claim that prolonged pain/injury after motor vehicle collisions is mostly due to psycho-social factors and whiplash-associated-disorder doesn't exist (it's literally crossed out and BDS...

This is a rather alarming and saddening conclusion!

It is notable that they never contest the fundamental methodological issues directly.

Reminds me of the glucose analogy that a certain someone likes to mention occasionally...

Interesting, that there were very few predictors of (incident) CFS and none of them had particularly large odds ratios.

I have a great deal of sympathy for newly ill patients who are not medical doctors, but MDs should know better.

Not uncommon, yet I still feel angry when I read of medical malpractice like this...

Glad this is finally off the ground! A quick question, will participants be able to access a set of their own genome data? This (at least in my opinion) would provide a strong incentive to be a part of the study.

Ugh, the nasal flu vaccine is trash. It's not approved for use in Australia for good reason! The rest of the article is not totally coherent, mentioning non specific "baseline inflammation" without explanation. The claims that the vaccine won't work for the older population is still pure...

His argument about elderly individuals is a non-sequitur. The reason why we have to test vaccines directly, is because seroconversion/antibody titres is not enough evidence to show the vaccine actually works. This is doubly so for SARS-2 vaccines, which are testing a variety of new and unproven...

There are only two ways to test the real-world efficacy of vaccines, a naturalistic randomised controlled study where you recruit a large population (tens of thousands of people) but only vaccinate half of them, and hope that many of them will be exposed to the infection. The other is to...

It's not any single thing that I'm looking for, but a list and hopefully we might spot some clear patterns.