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It actually suggests the opposite - CK spills over into circulation when muscles are damaged. What it really means is patients are less active than controls.

I must admit I did a double take there. If their symptom reporting is highly biased, then the concept of "people high on medically unexplained symptoms" makes little sense.

It is an interesting hypothesis, but is very much of house-of-cards construction, requiring a lot of empirical validation steps that could easily turn out not to be true. I do note they've singled out a few things that I have previously talked about in my random/speculative ideas thread, that...

I'm getting a bit bored of these retrospective questionnaire based studies. Why didn't the CDC or anyone else step up to the plate with a prospective community based study? I mean they've had 18 months to get one started!?!

This is certainly curious, but I'd like to see independent replication by another lab before I get too excited.

When I was 16, I'd have written a very angry piece about the ignorance of doctors that would almost certainly have been rejected...

The other viruses have become endemic because societies have tolerated them. We can eliminate this one with global vaccination and quarantine if we choose to do so.

Yes, without any sort of theoretical specificity it is just pseudoscience.

It sounds like the individual is still ill, but is just better able to manage what energy they have by pacing. The stuff about "boom-bust" just sounds like parroting what they were taught by a therapist.

I do find that strange, given her conclusion, namely that FND was a misdiagnosis and she actually had Sneddon’s Syndrome.

@Wyva Raw antibody titres vs vaccine effiacy from https://www.sciencedirect.com/science/article/pii/S0264410X21006587?via%3Dihub#f0005

So according to Betteridge's law of headlines, the answer is No!

I'm impressed that they've had such a long life span!

There are two issues here. The first is whether the test is a highly accurate measure of the antibody titre in the individual. I am suggesting it isn't due to sampling and processing variability. The second is whether the level of circulating antibodies will help prevent infection during the...

The FDA advice is correct, the tests do not indicate how "protected" you are. The tests are not reliable enough for any sort of quantitative prediction about "protection". The test shows that you have seroconverted and that is all that matters as far as the test goes.

Convenience studies like this don't provide direct evidence about cause-effect relationships like this, yet that is what they are trying to suggest in the conclusion...

It's funny how patients are never included as part of the Delphi method review group. No long-covid patients want this to be called "Post COVID Syndrome". One key problem with their criteria is that it poorly discriminates between individuals who have pulmonary damage and those who have other...

:nailbiting:

That would be more than "a bit dry"

@hope123 Additionally, I partially identify with the "Maria" case study (on a disability pension, no partner or kids), although I am much younger and have been ill since I was a teenager (and I have a different pattern of symptoms). I can tell you that the proposed interventions for Maria, are...