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I have had other doctors agree it is relevant. But what you are really saying is you don't agree, so why not? What about he frequent patient reports of patients reporting feelings of weakness, or rapid declines in performance when performing motor tasks? Almost all studies of motor performance...

Merged discussion moved from this thread No. In the case of motor control, fatigue is literally a reduction in performance for a given level of effort in the brain regions upstream of the motor cortex (eg Mesencephalic locomotor region). The sensations we associate with fatigue...

Yes, 6MWD are highly susceptible to biases of the order found in the trial (7.5% difference) because they are sub-maximal and easily susceptible to the participant simply choosing to walk faster or slower.

The relatively high sensitivity and specificity is rather curious. I'd like this to be replicated by blind examiners before getting too excited. The FMS pain score vs muscle pressure plot suggests the association is weak, but that could be due to too much variation in the anchoring of the pain...

It's likely to be hype. It would be the first time that a cytokine test has sufficient sensitivity for any illness besides the (by-definition) Cytokine release syndrome (commonly known as "cytokine storm").

I'm not convinced that it is. The unusual results on the 2 day CPET at the ventilatory threshold are not explained by autonomic disregulation that would result in impaired blood pressure or a delayed rise in heart rate upon standing from supine position (null results after a maximal exercise...

The MS pilot trial of Ketamine for "fatigue" didn't use actigraphy, but the proposed study which is supposed to include ME/CFS patients is planning on using actigraphy.

The Australian/Mike Musker study which monitored Leptin levels in circulation over 8 hours found no real association with severity or variation during the day. I'm not convinced that orexin is a key factor either, since our problem is not a disturbance of wakefulness like Narcolepsy.

Which is a stimulant and appetite suppressant. I'm not convinced this will work any more effectively than any of the other stimulants that have been trialed (dextroamphetamine, Methylphenidate etc).

FND is no longer a synonym for conversion disorder as many medical practitioners have abandoned the idea (due to a lack of evidence despite a century of looking) that symptoms are explained by "emotional charge" that is somehow "converted" into neurological symptoms as described by Freud. But...

Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel https://www.medrxiv.org/content/10.1101/2021.07.13.21260393v1 This is pre-delta, but I don't think delta would be much different.

https://clinicalstudies.info.nih.gov/ProtocolDetails.aspx?id=20-NR-0003 I don't understand why they think this. Both ketamine and midazolam will increase central fatigue. Edit - I think the expected mechanism is an analgesic effect... In the paper mentioned below, the authors speculate about...

It depends on the impairment and the type of rehabilitation. Work-focused rehabilitation, eg reduced hours is better than jumping straight back in once someone's sick leave finishes. Rehabilitation might be useful for those who have been hospitalised and have pulmonary impairment who have to...

Keeping in mind this patients who happened to attend a specific hospital, it is not an unbiased selection of patients. Only a prospective community-based study would lead to strong conclusions about the relationship between antibody response and Long Covid outcomes. The patients in general may...

Agreed. Too much reinvention of the wheel, as researchers pretend that this is magically different from ME/CFS and post-viral illness and thus are ignorant of prior research. I do worry that rehabilitation approaches will be misapplied - they can be helpful for patients who are spontaneously...

How about we ban wealthy people in having a say on tax increases?

That is due to risk of anaphylactic reaction, which is quite different to what the people in this study reported.

edit - I have read the paper now. The cases are unusual in that the patients claim symptoms appeared within 20 minutes of inoculation, but I cannot think of a mechanism that would cause the symptoms described that quickly. Also, note the note:

Which is weak evidence... Also, I'm not sure what the relevance of calcium channel function in NK Cells is to ME anyway. What occurs in leukocytes in circulation is not the same as what happens in other tissues... That said, it would be nice to have a proper double blinded LDN study, even if it...

"Rates"? The key is the severity. I've had a few friends who have had schizophrenia, their tiredness/lack of energy was mostly caused by a lack of sleep or medication side effects (or undiagnosed cancer causing a major hormone imbalance)...