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I guess... That diagram is yet another from the annals of nonspecific and meaningless medical illustrations. If he thinks it explains anything useful, he doesn't know much about biology.

I'm not convinced there are many insights to be gained by comparing patients to controls on a single CPET. Several of the observations could simply reflect the fact that the individuals have different activity (and fitness) patterns to controls. I'd be more excited about a low-flow scenario...

"well conducted trials". Quickly demonstrates their own bias...

In Australia, Methylphenidate prescription is heavily restricted, recipients MUST have been diagnosed with ADHD between the ages of 6-18 to receive it. (no adult ADHD diagnoses can receive it)

But all of that is just irrelevant non-sequitur. No one is suggesting that there is mind-body dualism and those examples don't explain the symptoms in question. In the latter example, the physiology is well known, measurable. Such bowel symptoms can also be induced by certain drugs stimulating...

We don't know that for sure. The numbers (particularly in vulnerable people) are too low to conclude that those with symptoms are protected from severe symptoms.

The Guardian science journalists not understanding what they are reporting on, once again. The study is a phase 2 study to test for safety. The sample size is not large enough for any conclusions of efficacy.

This might explain some of the distinct (albeit rare) neurological subsets, but probably doesn't explain most cases of long-covid.

All this suggests is the lack of specificity of the questionnaires and associated questionnaire answering behaviour in demarcating the conditions. The fallibility of the questionnaires has been regularly pointed out by patients, but it seems these researchers have not heard the message.

Sure, but availability of sintered glass has little to do with the decision to make a lower efficacy vaccine in favour of a higher example. That glass can be shipped from overseas where there is higher capacity too.

Patient narratives are important, but only when it's exactly what medical doctors want to hear!

The exercise wasn't trivial: The maximal heart rate function was from another paper: eMHR = 179 + 0.29 x age - 0.011 x age(2). This function underestimated my (1st CPET) maximal heart rate by about 25BPM! 70% of the predicted eMHR for me is significantly below the first ventilatory threshold...

In Australia, we have the luxury of waiting in terms of time. If people need a second dose to protect from new variants, it won't be AZ anyway, due to immunity against the vector. If you talk about supply chains etc, that's down to corporate licensing. The same facilities that make the AZ...

There has been a double blinded trial of methylphenidate that had positive results, though probably simply as a stimulant: https://www.sciencedirect.com/science/article/abs/pii/S000293430500656X

There isn't much new insight in the manuscript, but the review itself is decent, for those who don't know what drugs have been trialed and a few areas of interest that have been targeted.

I still haven't had a deeper look yet.

Looks exactly the same as I expected. The primary effiacy is still 66.7%. The difference in efficacy for LD/SD and the 12 week interval are almost certainly due to demographic differences. So the efficacy is around 80% in young healthy people and in the 60% range overall. The single dose had...

@Hilda Bastian's latest vaccine roundup https://absolutelymaybe.plos.org/2021/01/31/variants-3-new-covid-vaccines-and-contested-efficacy-claims-a-month-of-seismic-shifts-and-confusion/

Not necessarily. I mean it might be if they don't understand what central fatigue is. I still don't have access to the paper, so...

Why restrict it to illness? I'm reprogramming my genes with my mind to become a were-panthera as we speak.