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  1. Snow Leopard

    Who is Simon Wessely?

    Wow, that's brazen!
  2. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    1) It is extremely unlikely without engineering the virus. 2) It would make vaccine development even more critical. If the body already has an adaptive immune response to the virus, it will have a much easier time.
  3. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    On what time frame though? I mean it is likely they are going to repeat all the mistakes and irrelevant avenues that have been made with ME/CFS research first.
  4. Snow Leopard

    Covid-19 vaccines and vaccinations

    ~90% effective in whom? Efficacy figures that aren't based on randomised clinical trials and where there are significant differences in demographics aren't comparable (for example claims that the AZ vaccine has over 70%+ efficacy against symptomatic disease, when those subgroups where that was...
  5. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    I can't help but feel upset too, after being dismissed and ignored for so long. But it's almost as if they're simply feeling guilty that they didn't bother taking the initial actions that other countries did (e.g. Australia, NZ, Taiwan, Thailand) and continued to insist that young people will...
  6. Snow Leopard

    Maximal handgrip strength can predict maximal physical performance in patients with chronic fatigue, 2020, Jammes et al

    I was actually suggesting more of the former (afferent stimulation) than the latter. But low resting heart rate can be due to elevated parasympathetic activation of the vagus nerve innervating the sinoatrial node (the 'pacemaker') (though there is obviously a balance between parasympathetic and...
  7. Snow Leopard

    COVID-19: UK volunteers to be deliberately exposed to COVID in world-first trial

    If anyone dies as a result of this, I'm sure it will be remembered for a long time...
  8. Snow Leopard

    Covid-19 vaccines and vaccinations

    No, they've been warning such people to inform their healthcare providers and only be vaccinated in places where a quick medical response to an anaphylactic reaction is likely.
  9. Snow Leopard

    Maximal handgrip strength can predict maximal physical performance in patients with chronic fatigue, 2020, Jammes et al

    If handgrip strength is reduced on the second day, it strongly suggests central fatigue due to reduced cortical excitability. Which in turn is usually due to inhibition due to feedback from muscle afferents or reduced adrenergic drive.
  10. Snow Leopard

    Covid-19 vaccines and vaccinations

    The benefit really depends on what your risk of contracting the virus in the first place. If it is circulating significantly in your community (by that I mean people are contracting it in public from unknown contacts) then a vaccine dose usually outweighs the risks.
  11. Snow Leopard

    My Doctor Told Me My Pain Was All in My Head. It Ended Up Saving Me. 2021 Medical examiner article

    Yes, most people don't turn up in a pain clinic until they have severe unmanageable pain, usually at their wits end after trying everything obvious. "Pain neuroscience education" is unlikely to be effective beyond inducing the usual uncontrolled response biases on questionnaires that fool...
  12. Snow Leopard

    Covid-19 vaccines and vaccinations

    Yes, it can, the "original antigenic sin", or Hoskins effect. If the circulating antibodies still work to prevent sufficient activity in germinal centres (despite poorer neutralising ability), then the major result of a subsequent vaccine will simply be as a 'booster', eg clonal expansion of...
  13. Snow Leopard

    Covid-19 vaccines and vaccinations

    The author is missing the forest for the trees (as is easy to do as stated in the article). Any vaccine in your arm might have short-term benefit if the virus is currently circulating (which it is not in Australia), but the long term benefit is based on preventing spread and preventing disease...
  14. Snow Leopard

    The development of an instrument to assess post-exertional malaise in patients with myalgic encephalomyelitis and CFS (2018) Jason et al.

    My opinion is that you need BOTH objective evidence (to demonstrate impaired functioning) and subjective self-reports...
  15. Snow Leopard

    Edward Shorter’s view of Chronic Fatigue Syndrome

    Yes, so many of our stories don't fit his narrative at all. I was a child/teenager who had never even heard of it (or CFS!). I refused diagnoses for several years, with a strong expectation that my body was going to spontaneously recover! (children have minimal concept of chronic illness - I...
  16. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    Example of his COVID-19 research: https://covid19.elsevierpure.com/en/persons/jonas-f-ludvigsson "Children are unlikely to be the main drivers of the COVID-19 pandemic – A systematic review" "Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults"
  17. Snow Leopard

    A Molecular network approach reveals shared cellular and molecular signatures between CFS and other fatiguing illnesses, 2021, Comella et al

    The Kolmogorov–Smirnov test is a nonparametric test (does not assume parameterised statistical distributions). The figure does show higher viral load (log10cpm), but the Wilcoxon Ranked Test figure still shows largely overlapping distributions. The difference might still indicate something about...
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