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Some people are reporting worsening. (though this still doesn't imply anything specific about the pathology)

When the system is working normally, it leads to more oxygen available by the cardiopulmonary system for a given level of motor drive as I stated in my previous post. Perhaps I wasn't clear, there are many potential primary causes (some of which I mentioned), but there is some overlap in the...

The "common pathology" is that all fatiguing disorders are associated with central fatigue. We know this because the TMS, EMG studies regardless of pathology all have very similar results when fatigue is deliberately induced - central fatigue (EMG), reduced cortical excitability (TMS)...

Yes, it will never be a specific measure. The effect (reduced repeatability) is due to reduced cortical excitability (central fatigue) and is common to all fatiguing disorders, because it is mediated by peripheral afferent feedback - it doesn't matter if the illness is cancer related fatigue...

It's worse when they propose hypotheses that should already be ruled out due to ME/CFS research.

What you are saying is not mutually exclusive. In principle, defects of the fibroblasts can lead to defects in the collagen networks.

The irony is that it isn't society in general that has such prejudice (that causes stigma), it is a subgroup of medical practitioners that perpetuates it.

This sounds like a terrible idea. There are plenty of (what should be) innocuous topics by which to attract threats (that aren't annoying bullshit). Posting about how motorists endanger the lives of cyclists for example.

Claiming that the CSI predicts CWP and FM caseness, therefore it has "construct validity" is nonsense, it is circular logic. For them to claim construct validity, they have to demonstrate a high sensitivity and specificity for predicting objective pain related phenomena (eg actually measure...

I agree that we should take care not to get caught up in this side debate about mind-body dualism or "not psychological", because that debate is irrelevant!

There can be a clear behavioural component, in terms of risk (eg smoking for lung cancer, or diet for type 2 diabetes) and treatment compliance (if you don't seek treatment for a severe cancer...) But perhaps that is not what you mean?

It's funny how these "validation" studies never actually bother to ask the patients themselves as to whether they think it is relevant, reflective of their experience or for that matter, do the questions make sense?

These people have no interest in actually listening to the experience of people, they're just interested in pushing their politically motivated worldview. They're threatened by LongCovid because it suggests their policy of just letting young people get infected (because they'll get over it no...

This article seems to miss an entire chapter of history - what came before COVID. The reason why US authorities are so critical of AstraZeneca is because they have a history of not meeting their obligations. Their other vaccine, FluMist was marketed for several years (from 2013-2016, perhaps...

Quite frankly, that article is crap. The problem isn't merely clotting, the problem is that it's inducing a rare autoimmune thrombocytopenia condition which as been temporarily named "vaccine-induced prothrombotic immune thrombocytopenia". Yet that isn't mentioned in the article at all. It is...

For those mentioning benefits/side effects, can you state which dosages you tried? In Australia, there is 10 mg, 60 mg, and 180 mg slow release, I'd expect experience of side effects may vary as a result.

It's still all suggestive evidence, but I'd suggest something along the lines of "abnormal neurovascular coupling" too. This is also the most likely explanation for the frequent experience of headaches.

What Do Ducks Have to Do With Cancer? The QUACK model... (you always know research is of poor quality when cortisol is the central pillar of the hypothesis) Why even bother doing empirical science, when you can just publish hypothetical models like this?

3 weeks is more optimal for everybody in terms of germinal cell kinetics. (for the mRNA vaccines)

Yes.