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By the way Karl, in correspondence, highlighted that he fully supported the decision to fund GWAS. I won't be able to do it justice but when you don't know the cause of a disease then you can use techniques like GWAS to find clues --- I sort of think of it as scoring everything and then...

If you Google something like "glutamate MRI + Myalgic" then you'll see a bunch of studies. However, I wonder if they had adequate controls - or even how you would obtain adequate controls --- inactivity ---. Karl's results sound interesting; however, I guess that the Glutamate/Glutamine ratio...

Surely most of this suffers from the criticism re a "biased review" applies to these folks. They are pedalling this crap and they haven't been able to present evidence of objective benefit to patients. If they had taken the bother to contact their fellow Norwegian's Fluge, and Mella, (or simply...

I'm laughing --- I was hoping you'd review it - the laugh was a bonus - thanks.

I've had a very brief look at this: "Zonulin is a tight-junction protein and key regulator of intestinal permeability, with increased circulating levels suggesting a compromised intestinal barrier [6]". OK sounds interesting but I wonder if this suggests you should expand they type of [blood...

The other thing as @Jonathan Edwards the (Japenese) study, which found evidence of microglia activation, hasn't been replicated. Also, they used an old (not very specific) binding agent in that study; it was supposed to be replicated with one of the newer (more specific) binding agents but I...

There are reasons why the patient community should challenge the promotion of psychologic interventions, and graded exercise, which have no evidence base. I work at a junior level in a (non-health) public policy area [UK devolved administration]. You take a junior health policy official being...

Specualation- I vaguely recall something from a BBC Radio 4 program - possibly "All in the Mind". They featured an academic who possibly had won the lottery; she had listened to/analysed a serious of tapes of people going on a first date (stressful situation) and generated some "rules" which...

I haven't followed this or listened to the lecture. I didn't actually mind the principle of testing whether GET, and CBT, works for people with ME - as I type that I realise that GET for people with disabling fatigue, how do you get that past an ethics committee? One of the things which bugs me...

I've been meaning to post this; it's from last Fridays Independent Sage YouTube broadcast: "Over 1 million people had their 1st dose by 3rd Jan. Now over 3 weeks out. Are they tracking outcomes? Will they make them public? And by age?" - see slide 14 minutes from the start So I think the...

Yip I was reprimanded, by my significant other, when I relayed concerns [from this forum] about TG --- TG promoted the use of face masks ----. To be fair the concerns about TG [on social media] have now been acknowledged.

I think the other thing here is that the controversy may mean that the Government/politicians cannot support them (fund their research) i.e. ---Gerada, Greenhalgh, Garner, Vogt, Larun, Sharpe, Wessely, Fox, Wyller, Cochrane... If they are getting strong community support then the Government may...

I don't mean to be bitter or twisted here (it comes naturally!). I think Maureen Hanson's son is ill with ME and you can see how she's attempted to understand the disease [proteomics paper*]. If these people (TG+) applied the "you & yours test", my neighbour a casualty doctor refers to it, would...

It's occurred to me that this technique [aptamer-based proteomics] is similar to genome-wide association study (GWAS). I.e. you don't know what the cause [of ME] is and you measure everything - in the hope you find something different between people with ME & healthy controls. OK the authors...

Thanks. I'm laughing here - you obviously understand this much better than I do - which is great.

I recall this paper which compared Lyme and ME [https://pubmed.ncbi.nlm.nih.gov/21383843/] It's a protein study of Lyme and CFS - data is presented in the way you suggest. So yea, an update which used this technique Aptamers would seem to be in order --- would it need to be expanded to include...

Thank you Snow Leopard. Vaguely recall a guy in a corner of the lab (30+ years ago!) working on biotin binding ---- not sure that's at all relevant! I expect that once you've identified compounds of interest then you can determine them using other methods. E.g. if you Google "Ephrin-Eph + mass...

I need to look at the data but I think I formed the impression that the group of patients selected demonstrated an issue re Disrupted Ephrin-Eph and Immune System Signaling If that's correct then perhaps many people with ME have a similar underlying problem --- too early to say though.

"I've learnt a lot about my own body and about how to recover and like Clare, like the importance of gentle exercise and positive thinking to take you forward out of it..............." Gave me a laugh! What follows is pretty good too i.e. funny/hilarious. Maybe congratulate the interviewer...

I recall Jaime Seltzer [ME Action] saying this.