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Just found this by accident. Could someone send me a link to the original data/post. I was wondering if someone had checked the genetic data i.e. to see relationship between IDO2 mutation and incidence of ME/CFS. However, understanding even a small percentage of cases may help to explain the...

Only looked at this for a few minutes but what your saying seems reasonable. If IDO1/2 are not working then intracellular tryptophan will increase while intracellular kynurenine will decrease (Phair). It seems reasonable that intracellular Kynurenic acid will also decrease since it is formed...

Thyroid stuff is really interesting. However, I haven't kept up with it. If you search on-line then you'll probably find stuff linking thyroid function to ME/CFS e.g. see below*. Ron Davis's son is pretty much low in everything. Ron Tompkins (OMF - Harvard) in a recent interview highlighted...

Andy, this reminds me of something I meant to share. If you look at Fluge and Mella's Rituximab study then I think you'll find that they used activity monitors (I think there are relatively cheap options out there - not sure which option Fluge & Mella used). Anyway; I think readers should...

Response from FMMM1: In order to try to understand EU funding for research into diseases such as Lyme I did some Googling; I didn't find much but I did find this answer to a Parliamentary question: "The remaining two years of Horizon 2020, and in particular its forthcoming calls for research and...

The European Union Commission has funded Lyme research (33.9 million Euros) but has not funded any ME/CFS research. The headline budget for the EU (science and technology) Horizon 2020 programme is approximately 80 billion euros [https://ec.europa.eu/programmes/horizon2020/en/what-horizon-2020]...

Thank you very much for the link. I too know little about the European Commission but yes it decides how to allocate funding. E.g. the European (Union) Commission has funded Lyme research [33.9 million euros (approximately same US dollars)] ME/CFS research has received zero funding. Currently...

Thanks.

Hi I've managed to get three (written) European Parliamentary questions asked on ME/CFS: Alex Mayer (S&D) Reference :E-006901/2017 Rory Palmer (S&D) Reference :E-004360/2018 Mairead McGuinness (PPE) Reference :E-006124/2018 If you Google the reference then you'll see the question. I'll update...

Study is titled: "Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome" and it's available here: https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180469 I uploaded the wrong web address in my previous post Here's an extract from...

I've just received this "link to the complete version of the Red Blood Cell Deformability research paper" from OMF...

Thanks I think Ron Tompkins (spelling?) OMF pointed out that the expected cytokine storm in SEPSIS didn't occur/exist. I.e. cytokine levels weren't that high in SEPSIS - same goes for ME/CFS. Cort Johnson's article (see link above - in my original post) mentions this i.e. cytokines don't drive...

Thanks for your reply. I should have added a few caveats to my post; there's a lot of jumping between widely separated known pieces of this jigsaw. I don't know how to create a separate thread regarding lobbying; however, I' be grateful for advice/assistance.

Check out Fluge an Mella's (December 2016) paper "Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome" [https://insight.jci.org/articles/view/89376]. The authors state "According to this model, ME/CFS is caused by immune...

I wonder if it's variability in the sample or variability in the instrument; I assume that it's variability in the instrument. E.g. test same patient multiple times and the results vary (e.g. you can't reliably extract the PBMCs/extract tryptophan from PBMCs) or test the same sample multiple...

Jumbled thoughts: Prof Don Staines presented data, at the Invest in ME Research International ME Conference 2018, indicating problems with calcium regulation. I assumed that they would/had published that data. I assume that the energy problems demonstrated in this paper are proposed to be a...

I came across a reference to Comhaire on a blog I like (Follow ME in Denmark) which was discussing impaired pyruvate dehydrogenase (PDH) functioning in ME/CFS i.e. Fluge & Mella's 2016 study. The blog also refers to a study on those born with a genetic impairment of PDH (Patel et al: The...