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I had a brief look at this paper earlier; it looks like a bit of a monster i.e. there a lot of information here. I wonder if these findings fit in with Ian McGregor's theory (emerge conference last month) that ME is chronic sepsis. I.e. leaky gut produces chronic sepsis; altered metabolism...

I've struggled to understand this for some time i.e. rituximab kills B-cells and B-cells produce antibodies. On the face of it, if you have a B-cell autoimmune (auto-antibodies) disease then rituximab would successfully treat this. Are there other cells (not B-cells) which produce antibodies...

Based on a very brief glance, this article seems to suggest that Dr Naith believes autoimmune antibodies play a role in ME (http://simmaronresearch.com/2019/04/nath-chronic-fatigue-syndrome-east-african-disease-model/). The used "a kind of protein chip technology that allowed them to screen for...

ME is a convenient disease i.e. if your patient has unexplained fatigue then they have ME. I wonder if autoimmune disease is a similarly convenient diagnosis e.g. you may not even need to have an identified autoimmune antibody to be classified as having an autoimmune disease. An added...

@Jonathan Edwards I couldn't agree more Andy. I've been working with ME Action recently to try to lobby the European Union Commission to provide funding for ME Research. Lyme disease has received at least 33.9 million euros (last 10 years) for biomedical research from the EU Commission and ME...

Regarding IDO1 and IDO2: IDO1 is substrate inhibited i.e. at higher tryptophan levels IDO1 stops working. I.e. stops converting tryptophan to kynurinine; IDO2 takes over at higher tryptophan levels. So you need a substrate inhibited enzyme (like IDO1) and a second enzyme which operates at...

If you check out ME Actions material then you'll find references to a peer reviewed paper(s) on why certain diseases get funded beyond there impact (severity/numbers affected etc.) and others don't. E.g. HIV gets funded beyond the impact (3000 dollars per person with HIV) and ME gets nothing...

You've obviously looked at this more carefully than I have - good. Yes. Ron (from memory) said the Seahorse didn't work some times and they had no idea why (worrying). Also, he said it may be necessary to do two different tests (e.g. Seahorse type thing + another). Also (to repeat myself), Ron...

I've been able to watch some of the presentations here https://goliveaustralia.com.au/emerge2019/ However, I haven't been able to find Phair's talk - anyone know how to find it? @JaimeS @Esperanza My impression, after viewing this talk "Professor Paul Fisher: Specific mitochondrial respiratory...

Ron Davis highlighted that his son had a bacterial infection (from the line he has/had) i.e. not a virus. Derya Unutmaz is presenting at the NIH conference next month. Unutmaz is working on MAIT cells i.e. a type of T-cells which respond to nasty bacteria (riboflavin producing bacteria) in your...

Yea I can't understand why this hasn't been done by the lead agencies e.g. NICE in the UK. In terms of ME, we don't know if low thyroid function (low T3) presents as ME i.e. number of people with ME who are misdiagnosed - since they have low thyroid function rather than ME.

From my memory of the talk RNA virus's haven't been done yet; however, OMF are working on it. One view of the data is that virus's aren't relevant i.e. there are no active viral infections

Yea this makes sense i.e. everything is down regulated so why not thyroid function? However, it would be interesting to see a trial, i.e. in people with ME/hypothyroidism, to see if increasing T3 reduced fatigue in some people with ME.

Thanks @JaimeS here's an extract from the abstract which sums up the problem i.e. (I assume) false negatives in 20% of cases. "We suggest evaluation of thyroid hormone levels by ultrafiltration LC-MSMS for patients who continue to experience hypothyroid symptoms on LT-4. This may help identify...

Thank you for your reply. I should have found a better way to phrase my question. Maybe there is a mitochondrial element to the other conference.

I recall your prophetic words, i.e. dismissing T-cell clonal expansion as a worthwhile research area.

Hi @JaimeS I thought the low selenium and link to low T3 (thyroid) was really interesting. Is there a definitive test for thyroid function? It's just that (low) thyroid function seems to be similar to ME; however, we don't seem to be able to definitively say that people have/have not got low...

Check out the Barnden talk on MRI/Brain Stem. Only stuff I could view from the Conference presentations was strictly medical imaging (MRI etc.) no c--p about "multifactorial pathologic entity with lifestyle and constitutional/psychological makeup contributing factors" - whatever that means...

If you check out Cort Johnson (Health Rising) his highlights are "loved the Craddock one (most ununderstandable – but impressive) and the Barnden – love what he’s doing with the brainstem".‏ I could only watch the Barnden talk; seems like he's moved the whole MRI thing on significantly. The...

Haven't read this paper so these are just random thoughts. Some statistics relate to group comparisons so they say whether the control group was significantly different from the test (ME) group. I'd be interested in whether this test is good enough to diagnose people; presumably by demonstrating...