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Ron Davis (OMF) has been looking at red blood cell deformability in ME. However, I don't think they've reached the point where it's a definite yes/no i.e. a diagnostic test for ME or not. It's in one of Ron's video's. I noticed something last night on Health Rising; Cort has an article on ME...

At the EMERGE Conference Eliana lacerda (EUROMENE) gave a commitment that the EUROMENE biomarker group will: make recommendations on biomarkers (potential diagnostic tests) in February/March 2020 [10 to 12 minutes]. will advocate (lobby) European MPs (MEPs) i.e. to deliver the EUROMENE...

A lot has happened since this study was published e.g. the (reversible) fragmentation of mitochondria has been demonstrated (Bhupesh Prusty - NIH Conference last month). On the face of it, this method (RAMAN Spectroscopy) could be assessed against other techniques [SeaHorse, nano-needle...

In short I agree with you strategist - I've just used more words! Morten highlights Fluge and Mella's 2016 publication which as he (Morten) says demonstrates a blockage in the pyruvate dehydrogenase bridge (PDH). He states that the gene expression of PDH is about half of what you would expect...

Thanks @Trish. Ron Davis, speaking recently, said that when you ask an MS doctor whether (MS) patients have fatigue they say "yes but it's caused by MS not ME". I think Ron went on to say that doctors assume that all of your symptoms are caused by one disease. This supports your view i.e. some...

I'm with @Simon M here i.e. I'm not much interested in the black box bit; however, I'm very interested in whether it is a diagnostic test. Also, when will we see it delivered here in the UK/EU? ME Action are lobbying for the delivery of a diagnostic test...

Yea I remember reading a paper; the research (from memory) was done way before the paper was published. I read the conflicts section and yes they had a patent. So it occurred to me that the reason it took so long to publish the paper was that they delayed until they secured the patent.

If you test samples using the nano-needle and e.g. also: measure Oxygen Consumption [Karl Morten]; and/or measure the surface area/morphology [Bhupesh Prusty]; and/or remove the exosomes (filter plasma/serum) and re-test. Then presumably you can work out whether the nano-needle gives false...

I wonder if this technology will question current understanding of a range of diseases. I think Ron mentioned that there's fatigue in MS but of course the doctors say that's different. I'm not just thinking Lyme, or Fibro, here. Presumably there are a number of diseases which are mediated(?) by...

The nano-needle might give "a comparable signal --- in illnesses such as depression and anxiety" wow it might assist in those illnesses (or others) - great. I think the nano-needle might just provide a cascade of diagnostic tests i.e. for ME. Once you have a well defined group of people, with...

I think we need to be careful about saying that something is non biomedical - after all ME is claimed to be non biomedical. Ron Davis's nano-needle test etc. are forcing some rethinks about ME. Great posts by the way - thanks.

I think there's enough here [https://mecfsresearchreview.me/2019/04/25/something-in-the-blood/] to justify the funding of a validation study i.e. to develop at least one of these into a diagnostic test. Some of these methods even appear to be based on off the shelf technology e.g. Karl Morten...

I also got the impression Prusty was saying there were some infected cells. However, I would have assumed Ron Davis's, or Ian Lipkin's [AKA -the great virus hunter - Cort Johnson], teams would have found viral RNA/DNA in the blood - if there were virus's present. Of course, the detection limits...

I came across this after posting/before reading your replies and yes it refers to something new to me (at least) i.e. prions. From: https://www.frontiersin.org/articles/10.3389/fnins.2017.00026/full "Multiple Sclerosis and Inflammation Inflammation is a central player in most...

One thing that's slightly bugging me here. A virus (and as Bhupesh Prusty said potentially bacteria) can use mitochondrial fragmentation to evade the immune system. If we don't have a viral infection then why would our cells fragment the mitochondria? Surely if our cells identified a threat...

It appears that the thing they've been doing wrong is looking for the right things (microRNA's etc) in the wrong place i.e. blood serum/plasma rather than in the exosomes in the blood serum/plasma. To be fair to NIH, they gave a grant to James Baraniuk in 2015 to look at microRNA's in exosomes...

Yes. The first group who identified this were, as Bhupesh Prusty acknowledges earlier in his talk, Fluge/Mella (December 2016). Fluge/Mella used a Seahorse analyser which measures cellular energy metabolism i.e. by measuring "oxygen consumption rate (OCR) and extracellular acidification rate...

Noted and edited.

I hadn't known that i.e. that the PACE trial was funded by a Labour government, or, as @Andy has pointed out, that NICE guidance regarding CBT/GET predated the publication of the PACE trial [Lancet in February 2011...

When I looked at one of the slides Ron Davis presented (of Montoya's cytokine study) I thought I don't get this i.e. the results aren't that different for ME Controls/moderately ill/severely ill. Perhaps the P values indicated a significant difference between the controls and those with ME...