Search results

All above my head too and I couldn't be bothered trying to understand it. None of the following may be relevant to the theory presented in this paper! I think one of the problems with the active virus theory is that Ron Davis etc. can't find viral DNA (not much done on RNA virus's yet). To be...

I think $200 was the target. However, until we're sure it is diagnostic (at least of a problem - even if the same problem occurs in other diseases) then I'm not sure why you would adapt it for general release.

Hi @Perrier I wasn't able to watch Ron's presentation yesterday. OMF responded to my email on whether we can access this talk later: "We have requested a copy of the talk but we do not yet know if we will be receiving one. It is yet to be determined.--- If we do get a copy, we will send out an...

Anyone know if you can watch this after it has been streamed live? Emailed OMF here's the response: "We have requested a copy of the talk but we do not yet know if we will be receiving one. It is yet to be determined. Thanks, Debby Husch Administrative Manager Open Medicine Foundation...

Thank you very much for your replies. To me the mechanism are incredibly complex - but very interesting.

Please excuse further questions. Once the autoantibody can bind (IgG changes shape) then I assume this promotes the inflammatory process.

If you check out Jarred Younger's video link presentation in Sweden (last month), he discusses some recent experiments in brain imaging MRI etc. I assume that they've found further evidence of activation of microglia. He also discusses PET scans using a tracer (ligand); I think the idea is to...

Thank you very much for your reply.

Wow - you certainly understand this -- and if I understand correctly, you were very close to solving it. What I meant was there is a form of MS which does not respond to rituximab. As you highlight, this suggests that it is not B-cell autoimmunity. I wonder if symptomatically it looks like ME...

I assume that the other form of MS doesn't look like ME! I don't know anything about using Mass Spectrometry to gain information about the structure of a protein; however, I wouldn't have expected that it would provide information on protein folding.

I assume this is not relevant to the ME Community - at this point.

@Jonathan Edwards you're probably aware of the EU Funding under the "Marie Skłodowska-Curie Actions" [https://ec.europa.eu/research/mariecurieactions/node_en]. It seems to e.g. provide funding for scientists to work in other laboratories (possibly a researcher in the EU could work in a US...

Bhupesh Prusty found something in the blood caused increased mitochondrial fragmentation [NIH Conference April 2019]. So maybe that gives a clue to what something in the blood might be and what it's target receptor might be. E.g. this paper seems to link "adrenergic receptor signalling" to...

Jonas Bergquist found Pregnenolone to be significantly lower in people with ME [OMF funded study - https://let-me.be/e107_files/downloads/the_me_global_chronicle_-_30_-_20181222.pdf]. Not sure if this is relevant to this discussion.

I think ME is potentially a "wastebin to dump clinical cases of unexplained fatigue". E.g. MS (which also causes disabling fatigue) is caused by demyelination so you can diagnose cases of MS with a high degree of accuracy - I doubt it. I think this issue has also surfaced in the NIH Intramural...

Thank you very much for the translation. Interesting --- "The receptor system on the surface of immune cells is altered in ME/CFS patients, and this reduces the function of these cells and could also lead to erroneous signaling pathways in response to, for example, an antigen." I suppose...

Thank you very much for your reply; including your views on the likely significance.

Thank you very much for this. Solve ME/CFS have funded Bruno Paiva i.e. to work on "class II molecules of the major histocompatibility (MHC)"[https://solvecfs.org/bruno-paiva/]. I'm not sure how Paiva's work fits; HLA's, MHC's, --- it is all quite technical.

I think the clonal expansion of T-cells is unlikely to be interesting (hopefully I'm wrong). However, if talk deals with HLA and KIR sequencing then I'm certainly interested. Thank you very much. I'm particularly interested in whether Jonas mentions HLA or KIR sequencing. However, I'd pretty...

Haven't watched the video yet. I gather there were two projects i.e. Mark Davis's project on clonal expansion in CD8+ T cells (?) and Ron Davis's HLA study. I think I recall that Mark Davis's project on clonal expansion did not work out i.e. clonal expansion was found in the controls. However, I...