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Is there anything which should jump out in a GWAS study (or anything which has turned up in a GWAS study) which would support this hypothesis? EDIT - @Simon M - a GWAS study might give us clues here i.e. to see if there is indeed a basis for this hypothesis. Was the "key physiological finding...

I think this is a thing of beauty (you've probably highlighted it before) CBT for IBS ---- you wouldn't make it up. Do you do a microbiome test before, and after, CBT i.e. as an objective measurement of improvement ---?

I wouldn't expect it to be mandatory - why? because the efficacy is high (possibly 95%) and people who are vulnerable, and get vaccinated, may not get life threatening illness (necessitating ICU) --- so I wouldn't see a case for mandatory vaccination. If efficacy was low; therefore R=1 (or...

Just Google "Radio 4 Schedule" - you can access them via this link as well*: Episode 3 How to Vaccinate the World Tim Harford reports on what we know and don't know about the Oxford/Astra Zeneca Covid 19 vaccine with a panel of experts. *https://www.bbc.co.uk/programmes/m000py6x

There's a BBC Radio 4 program "How to vaccinate the world" which might help to provide some insight - a lot of these questions can't be answered yet --- once you've vaccinated a few million people, and time has elapsed, then you'll presumably have evidence of whether boosters are required and...

More money for ME specialists; @Jonathan Edwards has highlighted how rheumatoid arthritis treatment was turned around by specialists. However, as Jonathan has indicated, I wouldn't get your hopes up about getting more resources (e.g. to fund specialists). I assume (haven't followed this or read...

Does anyone know when they are due to start requesting samples? OK it may be difficult to be definitive i.e. due the pandemic.

I recall hearing something about the discovery of a potential mechanism for the action of lithium in bipolar disorder. The suggestion was that lithium modifies the shape of a protein and that leads to an improvement in bipolar symptoms. Immunoregulatory drugs successfully treat autoimmune NMDA...

Yip standard advice for policy folks: 1) evidence based policy development - that's the official Government stance; 2) policy based evidence development - your Minister wants something done --- go "develop" the evidence base!

I've heard that OMF plan to do a (Abilify) trial - anyone know anything about this?

I think it's used in bi-polar (type 2 bi-polar or some such) Who is the Jonathan you refer to?

I'd heard this before e.g. I think Maureen Hanson may have outlined the problem and solution ("ring fenced" or "set aside funding"); however, I'm impressed by the clarity/directness of Karl's message - thanks. @Michiel Tack @Giada Da Ros @EspeMor

Slightly unusual responding to your own post. I received a few questions re my post --- Chris Armstong found specific amino acids used- Chris's study was way back in 2015; subsequently Fluge and Mella added to that (2016) -- might be others Supplementation with amino acids - search this forum...

I think part of this is explained by @Jonathan Edwards "The problem is just that as a scientific question ME is very hard to see a way in to." If you take a clinical post in ME (if there is such a thing in the UK) then it's currently very difficult to treat people plus it's very difficult to...

Couple of researchers who might provide insight into lack of funding - Warren Tate and Carl Morten

I think I recall that you @Jonathan Edwards suggested that this was a reason a GWAS study was a good idea i.e. GWAS may give clues to the cause of ME. Bit about GWAS here* https://en.wikipedia.org/wiki/Genome-wide_association_study Also @Simon M (from memory) has highlighted that a number of...

I would have liked to see objective assessment of sleep disturbance e.g. using sleep monitors. Haven't tried to research it but the technique they used (1h-nmr spectroscopy) is generally considered to be a reference technique i.e. gives accurate results. Not sure about urea results "decreased...

Am I missing something or is this gibberish? Reminds me of the Sir Humphrey "which suggests that reversing deconditioning can lead to recovery" --- so the problem is lack of exercise (deconditioning) and the objective is to reverse that deconditioning? Surely the problem is the "dysregulation...

I'm planning to listen to the Radio 4 programmes How to vaccinate the world [https://www.bbc.co.uk/programmes/m000py6s/episodes/player] The presenter (Tim Hartford) was interviewed on BBC2 - Newsnight last night. I think one of his replies, re how long immunity would last, was - we'll just have...

Bit more from Robert Phair - haven't read them yet. https://forums.phoenixrising.me/threads/dramatic-improvement-in-mental-symptoms-from-melatonin-dosed-in-the-day.43606/page-2#post-2307414 There's also some stuff on the metabolic trap but it's only available to members.