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I wonder if it reflects the fact that the UK has lost control of the virus; therefore, they're forced to act.

I'm guessing that something which is not cleared/consumed at the normal rate would be present at higher levels i.e. since it accumulates. So yes increased production is not necessary. Chris Armstrong, & Fluge and Mella, demonstrated lower levels of certain amino acids --- presumed to be the...

I'm beginning to wonder if the UK regulator is being "awkward" i.e. asking for data!

I'd be prepared to be surprised --- How did they come up with 3 months apart? Thanks @Snow Leopard

When you put it like that, it appears to be relatively easy. However, possibly the problem is getting a proposed study through an ethics committee - which potentially suggests lack of evidence of efficacy @Sid

I assume this is the OMF/UK muscle research link Paul Greenhaff, PhD, Professor of Muscle Metabolism, University of Nottingham https://www.s4me.info/threads/omf-meet-the-team-at-the-me-cfs-collaborative-research-center-at-harvard-funded-by-omf.6128/

If e.g. there are particular problems/barriers in the US, then another option would be to do this in the EU, UK ----. In fact, Ron Tompkins (OMF Stanford), highlighted that they would be working with researchers in the UK to (among other things) get around issue of taking muscle biopsy's, from...

@Jonathan Edwards has pointed out that the rituximab trial was well conducted. I'd like to see a trial of aripiprazole-abilify in ME; however I wonder though would it only help a sub-group - I assume a well conducted trial would pick that up. The rituximab trial was expensive; however the cost...

@Snow Leopard you'll be relieved/reassured ;) to know that: "He [AstraZeneca chief] added he believes trials will show his firm has achieved a vaccine efficacy equal to Pfizer-BioNTech at 95% and Moderna at 94.5%."...

If this is significant in ME, then I assume that it would turn up in a gene expression study (microRNA) and/or genome-wide association study (GWAS) - correct? @Simon M

There's a Christmas post on MEAction Global by Janet Defoe/Whitney re Aripiprazole/Abilify - OMF are looking at the underlying mechanism for Aripiprazole/Abilify

Watching TV late last night (UK) and the BBC 24 hour news said that the Oxford vaccine would be approved in days!

Heard the same, from a neighbour who is a GP, i.e. the UK is about to start vaccinating with the Oxford vaccine (January). Not surprised about the "no choice" who would choose Oxford over the other 2?

Could you post a link to the (New York?) Times article - thanks.

Are there any more (cheaper) RNA vaccines reporting in the near future?

Maybe linked to the point @Snow Leopard made i.e. the Oxford vaccine might not be effective enough to achieve herd immunity (RNA vaccines are)

Particularly true when the vaccine is already being rolled out; i.e. reduce the level of transmission and get on with vaccinating people/ending the pandemic.

Seems the Moderna vaccine is stable*; however, I wonder if this will come down to cost - Moderna $25 - Oxford $2.5 -- 10X. Also, apparently they can tweak these RNA vaccines to make them more (temperature) stable. *"Refrigeration Storage: After thawing, to facilitate storage at points of...

Thank you @Snow Leopard if the new variant has higher transmissibility (OK that's disputed) then the vaccine may need to be more effective i.e. to achieve herd immunity.

I wonder if EU has rules re this; however, if you're not subject to an "external" regulatory framework then I guess that leaves flexibility.