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Just occurred to me the UK is pretty much running an experiment on whether 1 dose of vaccine is effective. E.g. if you check the number of people who have had 1 dose and been admitted to hospital after 1 month and before the second dose is effective --- maybe I've picked this idea up somewhere...

Only glanced at this but it reminds me of Bupesh Prusty's hypothesis i.e. ME is related to the effects of latent herpesvirus. Extract from paper: "The results indicate that fluctuating viral load, related to herpesvirus reactivation state, may play a role in ME/CFS pathogenesis, or might be a...

As @Snow Leopard said, I know this is speculative but I wonder what sort of clue/biomarkers would indicate this sort of problem?

I haven't followed this closely but the standard training for policy development involves an attempt to get you (policy maker) to approach the issue systematically. E.g. PESTLE - political, economic, science, technological, legislative, environmental or whatever. In this case Parliament has...

I contacted OMF and Linda replied "We have not looked into Campath". Perhaps they will look at it now. This seems an interesting way to get insight into the disease (ME) mechanism. @Jonathan Edwards

Thank you very much for your reply @Jonathan Edwards Re Campath-1H or something similar a bit like the Rituximab study then - wipe em out and see if it solves the problem. Is anyone aware of a large study of MHC sequencing in ME?

This is incredibly interesting @Jonathan Edwards - thank you very much. I wonder if there are any clues to the existence of the known (problem) T cell sub-groups in our genome and if another (problem) group could be identified via GWAS? What fingerprint would you expect to see in this type of...

Chris Armstrong (2015), and Fluge and Mella* (2016), have both pointed to increased metabolism of amino acids [specifically amino acids that bypass PDH/pyruvate "blockage" in the citric acid cycle]. Chris Armstrong is now being funded by OMF to look at protein (nitrogen) metabolism. Fluge and...

If you check on-line the shelf life in the fridge is long - so no issues with transporting it on normal (i.e. water) ice.

I think the selling point for Oxford/AstraZenica was that it was cheap [£5 versus £50 for Pfizer] and the UK had ordered enough to vaccinate 50 million people -- oh and the virus is now out of control and our hospitals are pretty much swamped.

I've belatedly followed @Jonathan Edwards advice re shopping i.e. click & collect --- drive through in my case. Additional veg shop - I've explained that I've a vulnerable family member so they bring the shopping out to the street --- like a kidnap exchange! I'd be similarly worried about my...

The Moderna vaccine should also be an option for home vaccination - the news from BBC etc. is that the Moderna vaccine should be available in the "spring"!

There was someone in the UK who published on ME affecting sight --- response times or some such.

Is there a simple way to measure perfusion "we were working on this hypothesis that chronic fatigue syndrome was caused by a lack of perfusion in those vessels to the muscles and other tissues"? Did the results turn up anything?

Thank you very much for your response - as always --- I may have to think through some parts of it though!

I don't feel I have a good understanding of PACE, but I'm slightly surprised by this "As someone who has designed and executed trials I could not fault PACE on that basis scientifically." The reason I say that is that those involved in PACE seem to have failed to incorporate adequate indicators...

Very interesting i.e. "persistent abnormal T cell activation in a hidden compartment". Would it be possible to test for this and if so then how?

Interesting that the consider that "a 12 week interval between doses, instead of the shorter interval, and they are saying that longer interval was what boosted immunity". Also I'd agree that "I think the roll out of whatever vaccine is available and approved is largely because of the very high...

Yes the key constraint, for the Pfizer (-70) vaccine but not Moderna (-20), is access to minus 70 freezers i.e. for longer term storage. Has anyone quantified "pretty good immunity --- without the second dose"? @Snow Leopard

Yes, I assume that they will continue using the Pfizer vaccine i.e. (as you indicate) the amount they've contracted to buy - same for Moderna. Combined enough to vaccinate 25 million people in the UK? I assume that if you get the Pfizer/Moderna vaccine then you'll get 2 doses of it ---...