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https://www.wordsense.eu/brain_fog/ "brain fog (uncountable) (informal) A mental condition in which the subject experiences problems in concentrating, thinking clearly, or remembering things. 1886, Mary Jane Holmes, Bessie's Fortune, G. W. Carleton & Co., page 261: Then, as the brain fog...

I think light sensitivity as part of the initial onset of migraine is fairly common but migraine itself is likely pathologically heterogeneous, so in both migraine and ME/CFS the symptom experience may be similar but the route to producing the symptom may vary between sufferers...

Twitter thread by article author:

Article: Science, Blots on a field ?, Charles Piller First para: "In August 2021, Matthew Schrag, a neuroscientist and physician at Vanderbilt University, got a call that would plunge him into a maelstrom of possible scientific misconduct. A colleague wanted to connect him with an attorney...

Seropositivity doesn't = illness, only past exposure to an infective agent. If health is impacted then a global patient population featuring 50+year old rural living males heavily concentrated in Eastern Asia (pop 1.7 bn) would make an interesting contrast to the current picture of Chronic...

Rather than anything substantive to me this paper feels like a Reformation era intra-sectarian counterblast where one group of theologians seeks to lay waste to another group that has suggested a particular scriptural interpretation is/is not heretical. Here's a more substantive counter...

Commiserations - it's always a bit depressing to find there's yet another form of garbage ME/CFS is going to throw at you. I'm not sure typical will show up here - my guess is that these 'sensitivities' get processed through the individual brain in somewhat individual ways. I'd experienced...

The 'nudge' concept has parallels with CBT, has appeared in Government policy “Nudge Unit” including in the area of welfare benefits: Nudging conformity and benefit sanctions: a state experiment in behaviour modification

PNAS Letter: Psychological and Cognitive Sciences, Maier, Bartos, Stanley, Wagenmakers, 2022 First para: Thaler and Sunstein’s “nudge” (1) has spawned a revolution in behavioral science research. Despite its popularity, the “nudge approach” has been criticized for having a “limited evidence...

The Eysenck Personality Questionnaire !!! Why any work by Hans Eysenck should still be considered valid is incomprehensible: Work of renowned UK psychologist Hans Eysenck ruled ‘unsafe’ Personality and fatal diseases: Revisiting a scientific scandal, Pelsoi, 2019 Abstract During the 1980s...

"my research isn’t diagnostic led, so as long as individuals have experience of chronic fatigue they can take part. No diagnosis required."

I think this is the kind of thing that changes people: https://www.theguardian.com/uk/2003/sep/14/animalwelfare.science for Blakemore it stopped being just about the science but the politics of what he understood science to be. Others clearly exploited that with their own claims of 'oppression'...

An in memoriam that doesn't mention CFS, or the minutiae of the SMC: Professor Sir Colin Blakemore FRS Blakemore may have been unhelpful in the cause of finding solutions to ME/CFS but he was an important scientist and science communicator.

I don't think there's anything 'invalid' in what the Griffiths Uni team are doing - it's the way lots of chemical physiology has progressed, teasing apart one element at a time. With TRPICs there's a range of related functions, all of which may operate in different ways...

I've no idea but given the range of diseases associated with peroxysomal dysfunction it seems unlikely that dietary modification would have a general application. The authors acknowledge the possibility of sub groups which suggest that a one fix fits all is going to be unlikely even if this is a...

Peroxisomal dysfunction ? If correct this would seem to have major implications for how we see ME/CFS: Handbook of Clinical Neurology Chapter 163 - Peroxisomal disorders Abstract The peroxisomal disorders represent a group of genetic diseases in man in which there is an impairment in one or...

Fever isn't something that has been recorded, and it's not something that patients typically complain of - however perhaps it should be an area of enquiry. N=1 low grade fever/chills were always part of my PEM experience. More broadly if ME/CFS were to involve immune dysregulation then perhaps...

American Academy of Family Physicians would seem to be the source of some of the unhelpful material: dated 2012 ! Chronic Fatigue Syndrome: Diagnosis and Treatment "SORT: KEY RECOMMENDATIONS FOR PRACTICE Clinical recommendation Evidence rating References Persons with chronic fatigue should...

Pelvic Congestion Syndrome : "Differential Diagnosis The list of the differential diagnoses for pelvic congestion syndrome is vast. It includes diseases of the urinary tract, gastrointestinal tract, musculoskeletal disorders, disorders of neurological origin, gynecological problems, and mental...

For thost asking what is The Unified Protocol ? Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Medical Conditions: A Systematic Review, Osma et al, 2021 full paper = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151777/ Abstract: "Emotional disorders are those...